Yes Clinic review
By Aminoscope editorial desk · Aminoscope
Check total and delivery
Our verdict
Yes Clinic offers clinician-reviewed compounded semaglutide with B12 and tirzepatide injections through monthly and prepaid plans. Six-month plans ship in two stages, and a separate oral semaglutide listing lacks a stated supply period.
Main trade-offs
- Refund amounts conflict with plan-price differences
- Tirzepatide cart and plan table disagree
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Compounded medicines are not FDA-approved. A licensed clinician must assess whether treatment is appropriate; availability does not establish safety or benefit.
Good fit
Adults comparing prepaid injection plans who can confirm the final cart price and possible follow-up lab costs.
Consider other options if
Readers who need an oral semaglutide monthly price or a fully settled cart and legal terms before intake.
Cost and care at a glance
- Category
- GLP-1 telehealth
- Published cost
- Semaglutide injection $199 monthly, $499/three months or $899/six; tirzepatide $259, $747 or $1,344 in the plan tables
- Medications
- Compounded semaglutide with B12 injection or oral semaglutide · Compounded tirzepatide injection
- Insurance
- Cash-pay, no insurance
- Availability
- Serviced U.S. states not listed
Our review in detail
Full assessment
The injection plan table is useful, but the six-month refund amounts conflict with that table. Check the cart total and written refund terms before paying; the posted legal terms also contain unfinished clauses.
What it is
Yes Clinic describes a telehealth marketplace connecting patients with independent licensed providers and U.S. pharmacies. It does not identify the treating group or dispensing pharmacy for a selected order in its public pages. A clinician decides whether to prescribe after intake.
How care works
The listed injection prices include an online clinician consultation, medication and shipping, with no membership fee. A six-month plan sends months one through three first, then an included month-three online check-in determines whether the provider approves months four through six. Some six-month plans may require separately paid repeat labs; the public pages do not identify which injection plans or the lab amount. The terms require adulthood and a serviced U.S. state but provide no state list.
Costs, billing and cancellation
The semaglutide with B12 injection page lists $199 for a monthly plan, $499 paid up front for three months and $899 paid up front for six. The tirzepatide injection page lists $259 monthly, $747 for three months and $1,344 for six. Its product widget also shows $249 without a selected plan, conflicting with the $259 monthly table; confirm the cart amount before ordering. Longer plans are one upfront payment without auto-renewal. The refund policy says a six-month plan returns the six- versus three-month price difference if the second delivery is not approved or the check-in is missed within 30 days. But it quotes $312 for semaglutide and $447 for tirzepatide, while the current plan prices differ by $400 and $597 respectively. Ask for the written refund amount that would apply to the selected plan. Yes Clinic does not bill insurance.
If a clinician declines to prescribe, the refund policy promises a full refund except for completed labs. An order can be canceled and refunded before pharmacy dispensing; after dispensing it is generally nonrefundable, subject to problems such as damaged or wrong medication. A monthly recurring plan can be canceled to stop future charges. The terms discuss possible consultation fees, while the injection pages and refund policy say consultation is included in these plan prices. The public terms also contain unfinished dispute-resolution and governing-law placeholders, so seek clear written terms for the selected purchase.
Medication and evidence
The semaglutide with B12 and tirzepatide injection pages each describe weekly compounded injections with provider-set doses. A separate compounded sublingual semaglutide product shows $597 without a stated supply or billing period, so that amount is not a monthly rate. Metformin ER is a separate oral medication, not a GLP-1. Compounded medicines are not FDA-approved branded products, and treatment is subject to clinician approval.
Sources checked October 26, 2026
Pros and watch-outs
What we like
- Injection prices shown for three plan lengths
- Staged six-month delivery described
- Consultation and shipping included in listed plans
Watch-outs
- Refund amounts conflict with plan-price differences
- Tirzepatide cart and plan table disagree
- Potential lab fee and unfinished legal terms
Best for
Adults comparing prepaid injection plans who can confirm the final cart price and possible follow-up lab costs.
Who should look elsewhere
Readers who need an oral semaglutide monthly price or a fully settled cart and legal terms before intake.
Research relevant to Yes Clinic
Explore the evidence and its limits. Findings apply to the formulation, route and population studied; they do not establish the quality or effectiveness of a provider’s products.
- What the semaglutide weight-loss trials actually showed
STEP 1, STEP 4 and SELECT, plus oral and higher-dose semaglutide trials: weight loss, withdrawal, cardiovascular benefit and the limits of comparison.
- Tirzepatide vs semaglutide for weight loss: what the trials actually support
SURMOUNT-5 found 20.2% versus 13.7% average weight loss. What that direct comparison supports, which doses it tested, and why newer formulations need separate evidence.
How Yes Clinic compares
A few alternatives worth a look, depending on what you’re optimizing for.
Enhance MDLab-guided treatment under ongoing physician oversight
See Enhance MD →- HealthRX
Low-cost compounded GLP-1 with overnight shipping and physician review
See HealthRX →
FoundMultiple medication pathways and insurance for clinical visits
See Found →
More GLP-1 telehealth reviews: Everlywell Weight Care+eMedMojoonEnhancedVirtualCare2GoGoodRx Care Direct
Editorial research
How we assessed this. This review reflects Aminoscope’s own read of Yes Clinic’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- What does a Yes Clinic six-month plan cost up front?
- The injection pages list $899 for semaglutide with B12 and $1,344 for tirzepatide, paid once. Months four through six ship only after the included month-three check-in and provider approval.
- How much is refunded if a second shipment is not approved?
- The refund policy says $312 for semaglutide or $447 for tirzepatide, but the current six- and three-month plan prices differ by $400 and $597. Confirm the controlling refund amount in writing.
- Why does tirzepatide show $249 and $259?
- The plan table says $259 for a monthly order, while an unselected product widget shows $249. Verify the selected plan's cart price before paying.
- Is the $597 oral semaglutide listing monthly?
- The public product page does not state a supply or billing period for that price. It cannot be treated as a monthly quote.
- Is Yes Clinic legit?
- Yes Clinic is a GLP-1 telehealth service. The medications it names are Compounded semaglutide with B12 injection or oral semaglutide and Compounded tirzepatide injection. Its stated availability: Serviced U.S. states not listed. What it publishes up front: Semaglutide injection $199 monthly, $499/three months or $899/six; tirzepatide $259, $747 or $1,344 in the plan tables. It is cash-pay and states it does not bill insurance. Before you pay, ask in writing about a single monthly price you can check before an intake and how its intake works.