AOD-9604 vs HGH Fragment 176-191
Two forms of the same growth-hormone tail. One was developed into a named obesity drug candidate and tested in people; the other inherited the marketing without the trial record.
AOD-9604
A GH-tail fragment with a clean safety record that reached human obesity trials — but showed no significant weight loss versus placebo, and the program was discontinued.
Full AOD-9604 evidence reviewHGH Fragment 176-191
The C-terminal tail of GH sold as 'the fat-burning part' — but its developed cousin AOD-9604 failed human obesity trials, and the raw fragment has no human trials at all.
Full HGH Fragment 176-191 evidence reviewSide by side
| AOD-9604 | HGH Fragment 176-191 | |
|---|---|---|
| Marketed for | Fat loss | Fat loss |
| Evidence grade | Clinical data | Preclinical / minimal |
| Family | GH axis | GH axis |
| Regulatory status | Not FDA-approved | Not FDA-approved |
| How it's obtained | Research-only | Research-only |
| Key human source | Wilding, Curr Opin Investig Drugs 2004 | Ng, Horm Res 2000 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
These are close chemical cousins, not competitors. HGH Fragment 176-191 is a synthetic copy of the last sixteen amino acids of growth hormone; AOD-9604 reproduces that same C-terminal region with a tyrosine added at the front, and it is the version that carries the clinical paper trail. That trail is unflattering: AOD-9604 advanced into a pivotal placebo-controlled obesity trial and failed to produce statistically significant weight loss versus placebo, after which the program was discontinued; it was, by the trial record, well tolerated, so it failed on efficacy rather than safety. The raw fragment sold today has no human efficacy trials of its own, meaning it is marketed on a mechanism whose one fair human test came back negative. Neither is FDA-approved; both circulate as unverified research-only material, and both are anti-doping detection targets.
AOD-9604 fits if
AOD-9604 is the one to study if you want the rare case where a fat-loss peptide was actually put through a placebo-controlled human trial, and what the answer was.
HGH Fragment 176-191 fits if
The Fragment 176-191 page is the one to read if you are being sold the raw tail peptide and need to see exactly which evidence belongs to it and which belongs to its developed cousin.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm AOD-9604 availability before ordering.
