DSIP vs Glycine
Two 'sleep' compounds separated by five decades of research maturity — a 1970s peptide whose own receptor was never confirmed, against a cheap amino acid with real modern sleep-quality trial data.
DSIP
Delta sleep-inducing peptide
A 1977 sleep peptide whose gene, receptor and real human benefit remain unconfirmed half a century on; only small, old, inconclusive human data.
Full DSIP evidence reviewGlycine
Aminoacetic acid, Gly
A genuine 4–6% lifespan result in the ITP and Mendelian-randomisation support for lower coronary risk — but the human sleep evidence comes from a single corporate lab and there is no collagen outcome trial at all.
Full Glycine evidence reviewSide by side
| DSIP | Glycine | |
|---|---|---|
| Marketed for | Sleep, stress | Sleep quality, collagen support, glutathione, healthy aging |
| Evidence grade | Clinical data | Clinical data |
| Family | Nootropic / cognitive | mTOR & other |
| Key human source | Kaeser, Eur Neurol 1984 | ITP lifespan study, Aging Cell 2019 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
DSIP is a 1977 sleep peptide whose gene, receptor, and real human benefit remain unconfirmed half a century later — only small, old, inconclusive human data exists. Glycine has a genuinely more modern and specific case: real trial data for sleep quality at a few grams before bed, on top of pennies-a-day cost and a clean safety record — though the deeper 'longevity' framing built on top of that sleep signal is mechanism-only.
DSIP fits if
You're reading about a historical sleep-peptide claim — be aware that basic questions about how it's even supposed to work were never resolved.
Glycine fits if
You want the cheaper, better-evidenced, easier-to-source option for sleep quality specifically.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm DSIP availability before ordering.
