DSIP vs Selank
Sleep versus anxiety, and two very different depths of evidence: Selank has small human anxiety trials, while DSIP's basic biology is still unsettled after nearly fifty years.
DSIP
Delta sleep-inducing peptide
A 1977 sleep peptide whose gene, receptor and real human benefit remain unconfirmed half a century on; only small, old, inconclusive human data.
Full DSIP evidence reviewSelank
A GABA-modulating anxiolytic that matched benzodiazepines in small Russian trials; the mechanism is credible but the evidence base is thin and single-country.
Full Selank evidence reviewSide by side
| DSIP | Selank | |
|---|---|---|
| Marketed for | Sleep, stress | Anxiety, focus |
| Evidence grade | Clinical data | Clinical data |
| Family | Nootropic / cognitive | Nootropic / cognitive |
| Regulatory status | Not FDA-approved | Not FDA-approved |
| How it's obtained | Research-only | Research-only |
| Key human source | Kaeser, Eur Neurol 1984 | Medvedev, Korsakov J 2015 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
Selank is the better-characterized of the two: a defined tuftsin analog with a GABA-modulating mechanism and small Russian trials that measured it against benzodiazepines. DSIP has no confirmed gene, precursor, or receptor, and its human record is chiefly a 1984 open trial in seven insomnia patients plus scattered 1980s work in pain and withdrawal, with no modern randomized placebo-controlled trial for any indication. Neither is FDA-approved and both reach US buyers as unregulated research-only material. Neither has been compared with the other.
DSIP fits if
DSIP is of interest mainly as a historical research curiosity for readers following the sleep-factor question, not as a sleep therapy.
Selank fits if
Selank is the more grounded read for anyone researching anxiety pharmacology outside the benzodiazepine class.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm DSIP availability before ordering.
