LevelUp Rx review

What it is

LevelUp Rx is a telehealth platform selling across a broad menu: a Longevity and Vitality shelf with NAD⁺ injectable, glutathione and B12; an Anti-Aging shelf with sermorelin and metformin; a testosterone line pairing testosterone cypionate 200 mg/ml with enclomiphene 6.25 mg; compounded semaglutide and tirzepatide for weight loss; plus hair loss, skincare, sexual health and general-health categories. Intake is a no-cost online consultation with no video required, reviewed by US board-certified physicians, and approved prescriptions ship free from its named partner pharmacies.

How it works

Asynchronous, storefront-led and unusually well documented on the dispensing side. Its FAQ names both partner pharmacies — DiRx in Fort Lauderdale, Florida and The DrugStore in Athens, Ohio — and states that a patient may direct a prescription to their own local pharmacy instead, which is a real piece of control most platforms do not offer. The no-cost consultation is bundled with the order, ongoing provider care and support is stated as included, and shipping is free with a syringes-and-alcohol-pads kit. What is not documented is who is prescribing. The terms name no distinct LLC or corporation — only "LevelUp Rx and/or our owners and/or affiliates" — no single medical group is identified, and the FAQ lists individual physicians for four states only, with governing law in Georgia and arbitration in San Diego. State availability is described as confirmed per therapy during intake rather than published as a list. And the refund position is firm: state and federal regulations do not allow the return of dispensed prescription medication, so all sales are final once shipped, though a subscription can be cancelled through your account before shipment.

Pricing transparency

Sermorelin is $195, and NAD⁺ injectable starts at $199 a month — both published on the product pages before any intake, which is what makes them usable. Read the sermorelin listing carefully: the same $195 appears against both a one-month and a three-month supply option, which is either a genuine bundle discount or a page error, and it is worth clarifying before ordering. The testosterone line is listed from $129, covering testosterone cypionate 200 mg/ml and enclomiphene 6.25 mg. GLP-1 pricing is separate and flat by design — compounded semaglutide $149.97/mo and tirzepatide $249.97/mo, stated verbatim as one consistent price whether or not your provider adjusts your dose, with six- and twelve-month plans available — but a flat GLP-1 rate is not a peptide price and should not be read as one. Before subscribing, confirm what a month's sermorelin supply contains and what the NAD⁺ "starting at" figure escalates to.

Branded vs compounded

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. LevelUp Rx states that compounded medications are not reviewed or approved by the FDA for safety or efficacy while noting compliance with Section 503A of the Federal Food, Drug, and Cosmetic Act, and it names the pharmacies dispensing them — which is more accountability than this board usually offers, though compounded sterile products are still not reviewed by the FDA for purity and potency. The molecules differ sharply in evidence. Sermorelin, described on its own page as injected once daily at bedtime at a custom dose, is a GHRH analogue with a real mechanism and thin long-term human outcome data. Injected NAD⁺, administered intramuscularly or subcutaneously per the product page, has no controlled human outcome trials at all; the oral precursors NR and NMN are the studied forms and what they demonstrate is a raised blood NAD⁺ level. Injectable glutathione has essentially no controlled human outcome data. Testosterone cypionate is the one product here with a large randomised safety base, and it needs ongoing haematocrit, PSA and testosterone monitoring that the site does not describe. Enclomiphene raises endogenous testosterone by blocking oestrogen feedback and preserves fertility, but is not FDA-approved for that use. Individual results vary.

Pros and watch-outs

The evidence behind what LevelUp Rx prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Sermorelin: a real GHRH drug, read against the anti-aging pitch

  An approved growth-hormone-releasing analog with a pediatric track record — and a longevity case built more on biomarkers than outcomes.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

• Glutathione: the master antioxidant, and where the evidence actually is

  Oral glutathione really does raise your body stores (a 6-month RCT proved it) — but the longevity and detox claims are unproven, skin-lightening is modest, and IV glutathione is the most marketed, least evidenced route. The precursors may be the smarter bet.

• TRT: what testosterone therapy is actually proven to do

  An FDA-approved therapy for diagnosed hypogonadism — with real but moderate benefits (sexual function, mood; not vitality), cardiovascular non-inferiority in TRAVERSE, and a real fertility trade-off.

• Enclomiphene: the evidence for restoring testosterone without replacing it

  Randomized trials, including two Phase III RCTs, show enclomiphene restores a man's own testosterone while preserving fertility — but it was never FDA-approved.

How LevelUp Rx compares

A few alternatives worth a look, depending on what you’re optimizing for.

• KOKongo

  NAD⁺ injections at a published flat rate across all 50 states

  See Kongo →
• LMLaSara Medical Group

  NAD⁺ buyers who want the concentration and vial size stated, not just a monthly price

  See LaSara Medical Group →
• LILiberty

  NAD⁺ from a platform that sources through 503B outsourcing facilities nationwide

  See Liberty →