Loop Health review

What it is

Loop Health, Inc. is a US membership wellness platform founded by Stephanie Gambetta. Its Loop Lean program covers compounded semaglutide and tirzepatide, and its wider menu includes sermorelin, NAD⁺, hair and skin peptides, sexual-wellness peptides, health coaching, bloodwork panels and weekly live sessions with clinicians, coaches and members. It connects members to an independent network of licensed providers rather than prescribing directly, and states it is not itself a healthcare provider.

How it works

Membership-first, with prescribing outsourced. You join, you are connected to an independent licensed provider who evaluates whether a peptide or GLP-1 is appropriate, and the compound is then prescribed and billed separately by the pharmacy. What the membership itself buys is stated concretely and is the genuine differentiator: clinician-guided care, 1:1 health coaching with monthly-or-more check-ins from a credentialed coach, weekly live sessions, bloodwork, protocols and a discount on Loop's own brands. Very little else in this category bundles coaching and lab panels around a peptide at all, and for someone who has previously bought a vial and then been left alone with it, that wrapper is the argument. The disclosure picture is thinner than the structure deserves. No medical director, no pharmacy partner and no LegitScript number appears on the homepage; coverage is described both as "select U.S. states where our provider partners are licensed" and as all 50 states, which are not the same claim; and the annual plan is what the site currently leads with, so treat any monthly figure you have seen elsewhere as needing confirmation.

Pricing transparency

The membership is priced and the medication is not. Loop lists $1,500 a year, including a $180-a-month credit applied to peptides, panels and add-on packages — and a credit applied toward peptides is itself the disclosure that peptides are billed on top, not included. Its pricing page states that compounds are prescribed and billed separately by the pharmacy, so no sermorelin or NAD⁺ figure appears anywhere on the public site and we are not quoting one. That is the number to chase before joining: ask what sermorelin and NAD⁺ actually cost through the pharmacy network, whether the $180 credit rolls over or expires monthly, what happens to unused credit if you cancel, and what the cancellation terms are, since they are not published. A membership plus an unknown medication cost is not comparable to a flat $115 or $199 monthly price elsewhere on this board until you have both halves.

Branded vs compounded

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. Loop's own disclaimer is admirably specific — compounded drugs, including compounded semaglutide and tirzepatide, have not undergone FDA premarket review for safety, effectiveness and quality — and it does not name the dispensing pharmacy, so the usual caveat applies that compounded sterile products are not reviewed by the FDA for purity and potency. On evidence, sermorelin is a GHRH analogue that prompts your own pituitary to release growth hormone; the mechanism is real and well described and the long-term human outcome data behind the body-composition and recovery claims stays thin. Injected NAD⁺ has no controlled human outcome trials — the single human intravenous study was a pharmacokinetic pilot showing infused NAD⁺ clears from plasma quickly — while the oral precursors NR and NMN reliably raise blood NAD⁺, a raised biomarker rather than a demonstrated clinical benefit. The coaching and bloodwork wrapper does not change any of that, though it does mean someone is watching your labs while you take it, which is more than most of this board offers. Individual results vary.

Pros and watch-outs

The evidence behind what Loop Health prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Sermorelin: a real GHRH drug, read against the anti-aging pitch

  An approved growth-hormone-releasing analog with a pediatric track record — and a longevity case built more on biomarkers than outcomes.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

How Loop Health compares

A few alternatives worth a look, depending on what you’re optimizing for.

• LILifespanningRx

  A certified NAD⁺ program if you will complete an assessment before seeing a price

  See LifespanningRx →
• KOKongo

  NAD⁺ injections at a published flat rate across all 50 states

  See Kongo →
• LHLevers Health

  NAD⁺ injections priced openly on a storefront rather than quoted after intake

  See Levers Health →