Yucca Health review

What it is

Yucca Health is a cash-pay telehealth platform operated by Brand Merchants Network LLC of Beverly Hills, California. It runs the intake, patient portal, payments, pharmacy coordination and support, while prescribing is done by licensed clinicians in partner provider networks and dispensing by licensed U.S. pharmacies in partner pharmacy networks. The specific clinician and pharmacy for your order appear in your portal once it's processed, and the pharmacy's details are on your prescription label; Yucca says a certificate of analysis is available on request, and that it will send your prescription to another pharmacy if you ask, where it can. Alongside the weight-loss line it sells compounded NAD⁺ and sermorelin on three-month plans. It says it is LegitScript certified, and displays the seal.

How it works

Asynchronous. You answer an online questionnaire about your history, habits and goals, choose a plan, and a licensed provider authorized in your state reviews it, typically within 24 hours, messaging you if they need more detail. No live appointment is needed. Once approved, the pharmacy prepares your medication in two to three business days and ships it by UPS 2-Day Air at no charge, with tracking by email. Your price stays flat as your clinician titrates your dose, usually holding each level at least four weeks before stepping up, and Yucca is explicit about safety: its FAQ warns that milligrams and syringe units are not the same thing and tells you not to inject if your dose is unclear. Eligibility is a BMI of 30, or 27 with a weight-related condition, with BMI 25 considered depending on history. Ongoing care runs through the patient portal, where you message your care team, track progress and change treatment.

Pricing transparency

Semaglutide is $146 a month on the monthly plan, $420 every three months ($140 a month) or $750 every six months ($125 a month). Tirzepatide is $258 a month, $744 every three months ($248) or $1,350 every six months ($225). There is no membership fee, and the consultation and shipping are included. Yucca's "locked pricing" holds your price for that medication and billing cadence as long as your plan stays active, including dose increases; switching drugs or billing cadence, canceling or letting a payment lapse ends the lock, while pausing keeps it. You're charged once a clinician issues your prescription. Before that point you can cancel for a full refund, and if a clinician turns you down, you get everything back, including the consultation fee. After the prescription is issued, the order is final, even if it hasn't shipped. To stop a renewal, cancel at least seven days before the renewal date. Early exits from multi-month plans are reviewed case by case, with no pro-rating. Buy Now Pay Later (Affirm, Klarna, Afterpay) is offered at checkout. The 6-Month Promise, for GLP-1 injection plans started on or after September 18, 2026, refunds everything you paid over six months if your final logged weight is equal to or higher than your starting weight, and only if you logged a starting weight, every dose within 72 hours and at least 20 of 26 weekly weigh-ins with no gap over three weeks. It can be claimed once.

Branded vs compounded

Compounded semaglutide and tirzepatide by weekly injection, plus compounded NAD⁺ and sermorelin on the longevity line. Yucca states that compounded medications "are not FDA-approved and are not reviewed by the FDA for safety, effectiveness, or manufacturing quality." Its treatment pages cite the branded trials accurately, including semaglutide's 14.9% average loss at 2.4 mg over 68 weeks and tirzepatide's 15% to 20.9% across doses, and say plainly that "anyone who tells you a number for your specific case is guessing." Those results belong to the branded drugs, and compounded versions haven't been through the same trials. Brand-name medication isn't offered.

Pros and watch-outs

The evidence behind what Yucca Health prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• What the semaglutide weight-loss trials actually showed

  STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.

• Tirzepatide vs semaglutide for weight loss: what the trials actually support

  Most comparisons are cross-trial. Only SURPASS-2 and SURMOUNT-5 randomized one drug against the other — here's the precise distinction.

• Compounded vs branded GLP-1: regulatory status, sourcing and the evidence

  Compounded GLP-1 isn't FDA-approved, the shortage exception behind it ended in 2025, the FDA moved against mass-marketed copies in 2026, and the trial data belong to the branded product. Here's the precise picture.

• NAD+ injections: benefits, side effects, cost and what the evidence says

  Subcutaneous NAD+ is sold as a cheaper, at-home alternative to the IV drip, through “near me” clinics or telehealth shipped to your door. It’s compounded, not FDA-approved, and has no outcome trials; oral NR/NMN precursors are the route with the human data.

How Yucca Health compares

A few alternatives worth a look, depending on what you’re optimizing for.

• yourEra

  A low-cost entry point into compounded GLP-1 treatment

  See yourEra →
• Direct Meds

  Straightforward compounded GLP-1 without an insurance requirement

  See Direct Meds →
• Trimi Health

  Low-cost compounded GLP-1 with thorough dosing guidance

  See Trimi Health →

More GLP-1 telehealth reviews: Layla · Lean Rx · LeanDose · LevelsRx · LifeRx.md · Livea