TMates review

What it is

A telehealth platform selling testosterone cypionate as an intramuscular injection, NAD⁺ as both a subcutaneous injection and a nasal spray with the concentration stated, sermorelin as a subcutaneous injection, compounded semaglutide and tirzepatide, phentermine, minoxidil, hydroquinone and an erectile-support product — plus branded Zepbound and Wegovy offered as a prescription-referral service rather than dispensed. It positions itself as a technology platform rather than a medical provider, stating that it does not practise medicine and that the treating providers are independent.

How it works

Telehealth only, with no in-person visits, and asynchronous intake marketed as instant — a 90-second quiz to get pre-approved, then licensed provider review, labs if ordered, approval and shipping. Pricing is not gated: full plan tables render publicly on every product page. For testosterone, labs are included in the price and periodic lab work is described as part of the process, with the diagnosis explicitly gated on lab-confirmed low testosterone. Two things to read carefully before subscribing. The "cancel anytime" on every tile sits against terms that are considerably harder — no refund once the medical team has reviewed and a prescription has been written and transmitted to a pharmacy, and payment plans remain in place even if a refund request is declined. And the site names nobody: its own doctors page lists zero physicians, zero NPIs, zero photographs and zero state licences, offering only aggregate claims about board certification and average experience, while displaying Harvard, Mayo Clinic and NIH logos with no stated relationship and no named clinician to attach them to. No compounding pharmacy is named either, though the company states candidly that it is not itself a 503A or 503B facility. A practical note for anyone re-checking these figures later: the site hard-blocks automated fetching, so it can only be read in a real browser.

Pricing transparency

Two sets of numbers, and only one of them is a monthly price. On the product pages, the default selected plan is the true monthly rate: testosterone $200 a month, NAD⁺ $149, sermorelin $179. Prepaid bundles then step down — testosterone to $450 for three months, $700 for six and $1,000 for twelve; NAD⁺ to $1,050 for twelve; sermorelin to $1,550 for twelve. Those are legitimate offers, honestly laid out on the product page with the total shown. The shop grid is where it goes wrong: it lists each product with a "/month" suffix using only the deepest annual rate and discloses no commitment on the tile — testosterone "From $83 /month" against a real $200, NAD⁺ "From $88" against $149, sermorelin "From $129" against $179. The testosterone gap is 2.4×. A separate problem sits in the same grid: branded Zepbound and Wegovy are listed at "$99 /month" in the same format as products whose price includes the drug, when the product page states that $99 covers clinical service only and that TMates does not dispense or ship the medication — the drug is paid for separately at your own pharmacy. All three cards here therefore quote the product page and name the prepay total explicitly.

Branded vs compounded

Compounded; not FDA-approved for the compounded line, and TMates' footer disclaimer states that correctly — compounded medications are subject to quality and purity standards but are not evaluated by the FDA for safety, quality or efficacy — with proper trademark disclaimers and an unusually candid statement that it is not a 503A or 503B compounding facility. No compounded product is called FDA-approved anywhere, which is more than several competitors here manage. The problems are elsewhere. Its patient testimonials call a prescription NAD⁺ injection a "supplement" twice, on a page that sells it as provider-reviewed and prescription-only, and the same two quotes appear on the sermorelin page, where they are about the wrong product entirely. Its NAD⁺ FAQ raises the evidence question honestly and then waves it away: asked what the controversy is, it answers that some say the claims exceed current research "but the results patients are getting speak for themselves". On testosterone, two clinical statements need correcting — it claims most experts agree subcutaneous injections are not as effective, which is not the consensus and sits against an FDA-approved subcutaneous testosterone auto-injector, and it presents 200 mg injected weekly as a typical starting dose, which is high against conventional starting regimens nearer 100 mg weekly or 200 mg every two weeks. Its sermorelin page also claims to be "a safer alternative to direct HGH supplementation", a comparative safety claim with nothing behind it. On the evidence: injected and intranasal NAD⁺ have no controlled human outcome trials; sermorelin acts on a real growth-hormone axis with thin long-term outcome data; testosterone replacement has a large randomised safety base and requires ongoing monitoring. Individual results vary.

Pros and watch-outs

The evidence behind what TMates prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Sermorelin: a real GHRH drug, read against the anti-aging pitch

  An approved growth-hormone-releasing analog with a pediatric track record — and a longevity case built more on biomarkers than outcomes.

• NAD injections: how to get them near you or online, and what the evidence really says

  Subcutaneous NAD+ injections are sold as a cheaper, at-home alternative to the IV drip — via “near me” clinics or telehealth shipped to your door. They’re compounded, not FDA-approved, and have no outcome trials; oral NR/NMN precursors are the route with the human data.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

• TRT vs natural testosterone: what actually works?

  Losing excess weight and fixing short sleep genuinely raise testosterone; exercise helps mostly via fat loss; zinc and vitamin D only if you're deficient; and most 'boosters' don't work. When that isn't enough, TRT is.

• Low testosterone treatment: the stepwise options that actually work

  Confirm it's real, fix any reversible cause (weight, sleep, medications) first, then choose the medication — TRT for confirmed hypogonadism, enclomiphene or hCG when fertility matters.

How TMates compares

A few alternatives worth a look, depending on what you’re optimizing for.

• OLOak Longevity

  Low-cost sermorelin within a broader longevity stack

  See Oak Longevity →
• HEHealthRX

  Compounded sermorelin within a broad longevity and weight-care menu

  See HealthRX →
• BHBodybuilding Health+

  Pairing sermorelin with a strength-training and recovery focus

  See Bodybuilding Health+ →