Youth & Soul review

What it is

Youth & Soul (youthnsoul.com) is a multi-vertical longevity marketplace selling doctor-prescribed telehealth programs across eight or more categories — weight loss, menopause and HRT, sexual health, longevity, skin and hair, brain, gut health and mental health — each priced as tiered protocol bundles rather than as individual drugs. Its Longevity & Vitality program runs three tiers: Cellular Defense at $99/mo (methylene blue and metformin), Growth Hormone Optimization at $149/mo (sermorelin/ipamorelin injections, sublingual NAD⁺ 250 mg, methylene blue, and an IGF-1 and hormone panel review) and Ultimate Longevity Protocol at $299/mo (sermorelin/ipamorelin, injectable or nasal NAD⁺ 500 mg, BPC-157, low-dose naltrexone, methylene blue and a longevity blood panel). BPC-157 also appears inside its pain and gut tiers.

How it works

Asynchronous intake into a bundled program, with the clinical layer outsourced and now named. Its disclosures state that the on-site assessment does not establish a doctor-patient relationship, that Bask Health — described as a network of US-licensed physicians — sets the exclusionary criteria and conducts a consultation after checkout, and that all prescribing decisions rest with the treating clinician. Compounded medications are stated to be prepared by a US-licensed 503A pharmacy, which is not named. The compliance improvements since our record are real and worth stating: a LegitScript seal with certificate number 51182633 is now displayed with a link to the public checker and a dedicated Trust & Compliance page, and the falsely applied FDA-approved badge no longer sits over the compounded line — the only FDA-approved labels now attach to brand Wegovy and Ozempic pens, which it has added and which genuinely are approved. Three marketing problems survive and a reader should weigh them. The trust strip presenting large user and order counts is labelled "Powered by Bask Health" and its own affiliate page describes those totals as spanning the vendor's entire backend across all its clients, not this brand. The testimonial marquee carries a footnote stating it takes reviews "from across the internet" while the adjacent copy promises never to fabricate results — those two statements sit badly together. And the how-it-works step copy still runs a scarcity line, "Currently 3 Telemed Doctor Consultations Available Today". No operating entity is named anywhere on the site.

Pricing transparency

Published per tier and never per molecule, which is why we quote no floor on either board. The Longevity program's middle tier is $149 a month and its listed contents are sermorelin/ipamorelin peptide injections, NAD⁺ sublingual tablets at 250 mg, methylene blue, an IGF-1 and hormone panel blood work review, physician monitoring with dose optimisation, sleep and recovery tracking and free shipping. The top tier is $299 a month and swaps the sublingual NAD⁺ for injectable or nasal NAD⁺ at 500 mg while adding BPC-157, low-dose naltrexone 1.5–4.5 mg, a comprehensive longevity blood panel, weekly physician check-ins and a biological-age assessment. The entry tier at $99 contains no peptide and no NAD⁺ at all — just methylene blue and metformin — so it is not an option for a reader on either of our boards. Stating milligram strengths inside a bundle is better practice than most competitors manage, and the tiers do include blood work, which many peptide sellers skip entirely. But $149 is not a sermorelin price and $299 is not an NAD⁺ price, and treating either as one would misrepresent both to anyone comparing against a single-molecule seller. Its state coverage claim — ships to all 50 states — appears inside a comparison table against named competitors rather than as an enumerated list.

Branded vs compounded

Compounded; not FDA-approved, alongside a newer branded line where the approval claim is legitimate. Prescription required only if a licensed clinician finds it appropriate, with Bask Health named as the prescribing network and a US-licensed 503A pharmacy stated but not named. Compounded sterile products are not reviewed by the FDA for purity and potency the way approved drugs are. On the evidence, the bundling is the problem this section has to flag, because a tier starts several therapies at once and you will not know which one did anything. Sermorelin and ipamorelin act on the growth-hormone axis — real mechanisms, thin long-term human outcome data. Sublingual, injected and intranasal NAD⁺ all lack controlled human outcome trials; the oral precursors NR and NMN are the studied forms and raise a blood level rather than demonstrate a benefit. BPC-157 has no controlled human outcome trials at all; its tissue-repair reputation rests on rodent work. Methylene blue is an approved drug for methaemoglobinaemia being sold here for mitochondrial and cognitive claims that have no controlled human outcome trials behind them, and it interacts seriously with serotonergic medications including SSRIs — raise every medication and supplement you take at intake, because it appears in all three longevity tiers. Low-dose naltrexone is an off-label use of an approved molecule with limited controlled data. Individual results vary.

Pros and watch-outs

The evidence behind what Youth & Soul prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Sermorelin: a real GHRH drug, read against the anti-aging pitch

  An approved growth-hormone-releasing analog with a pediatric track record — and a longevity case built more on biomarkers than outcomes.

• Ipamorelin & CJC-1295: the honest evidence on GH secretagogue peptides

  They reliably raise growth hormone — that part is real. The muscle, fat-loss and anti-aging claims are not supported by human outcome data. A straight read.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

• NAD injections: how to get them near you or online, and what the evidence really says

  Subcutaneous NAD+ injections are sold as a cheaper, at-home alternative to the IV drip — via “near me” clinics or telehealth shipped to your door. They’re compounded, not FDA-approved, and have no outcome trials; oral NR/NMN precursors are the route with the human data.

• NAD⁺ nasal spray: the delivery format with the least direct evidence

  Intranasal NAD⁺ is convenient and heavily marketed — but no controlled human trial shows the spray raises systemic or brain NAD⁺. A straight comparison with the better-studied routes.

• BPC 157: what the evidence actually shows (and what it doesn't)

  The 'healing peptide' has a deep rodent literature and almost no human data. A straight read of where the science stands.

• Methylene blue: the longevity 'biohack' that's actually a drug

  Low-dose methylene blue has a plausible mitochondrial mechanism and a real single-dose memory signal — but it's an FDA-approved drug, not a supplement, its anti-aging claims are preclinical, and it can cause fatal serotonin syndrome with antidepressants.

• Low-dose naltrexone: what the evidence actually shows

  LDN is a 50 mg drug taken at 4.5 mg for pain, autoimmune disease and fatigue. The TLR4 mechanism is real and interesting — but the small fibromyalgia pilots and the large one disagree, and that contrast is the whole story.

How Youth & Soul compares

A few alternatives worth a look, depending on what you’re optimizing for.

• WWWhoosh Wellness

  NAD⁺ buyers who want the injection and the nasal spray priced identically and all-in

  See Whoosh Wellness →
• PLPlexusDx

  NAD⁺ at a published all-in monthly price with check-ins and no membership on top

  See PlexusDx →
• PAPauseRX

  NAD⁺ buyers who want a named 503A pharmacy and a named prescribing network

  See PauseRX →