Wholesome Clinic review

What it is

Wholesome Clinic, LLC is an integrative psychiatry and wellness practice based at 7978 Preston Road in Frisco, Texas. Its main work is mental health care, including Spravato treatment for depression, but it also offers medical weight loss, virtual primary and urgent care, and perimenopause and menopause care. Weight-loss patients see Stephanie Ukoha, a nurse practitioner with a Doctor of Nursing Practice degree and dual board certification in family and psychiatric care, licensed in all seven states the clinic serves; she reports more than 18 years in health care and over a decade as a nurse practitioner. A collaborating psychiatrist is listed in a supervisory role but doesn't see patients. Telehealth is available in Texas, Colorado, New Mexico, Oklahoma, Louisiana, Oregon and Arkansas, and you must be in one of those states at the time of your visit. Local patients can also be seen in person in Frisco, though weight-loss injections are always self-administered at home.

How it works

You book a virtual consultation online or by phone, and same-week appointments are often available. Before the visit, the clinic requires baseline labs: a comprehensive metabolic panel, fasting glucose or A1c, a lipid panel, TSH and a pregnancy test where relevant. Results from the past six to twelve months may be accepted, and patients without insurance can order panels through the clinic's discount lab store. The first visit is a 30- to 45-minute video evaluation covering your history, medications, labs, prior weight-loss attempts and GLP-1 precautions such as thyroid, pancreatitis and gallbladder history. The provider then lays out the options, from compounded oral or injectable medication to brand-name Wegovy or Zepbound through insurance, or another approach such as phentermine, Contrave or orlistat. Prescriptions are issued only when appropriate. Compounded plans ship to your home, while brand-name prescriptions go to your local pharmacy. Follow-up visits every four to eight weeks for dose changes and side effects are built into the monthly plan.

Pricing transparency

The compounded plans are all-inclusive: the clinic says the monthly rate covers your medical evaluation, the medication and home delivery, with no separate visit charges. Semaglutide is priced by stage. Injectable semaglutide with B12 is $159 a month for the first two months at 0.25 mg, $189 for months three and four, $219 at month five and $249 at the 2.4 mg maintenance dose. Oral semaglutide tablets with B12 run $159, $189 and then $229. Oral tirzepatide tablets are $249 at 3 mg, $299 at 4 mg and $349 at 5 mg, and injectable tirzepatide with niacinamide is $349 at 2.5 to 5 mg, $449 at 7.5 to 10 mg and $549 at 12.5 to 15 mg. If the provider decides during your first visit that medication isn't appropriate, the clinic keeps a $99 evaluation fee and refunds the rest of your first payment. Labs are extra. Patients who choose a brand-name drug or an older oral medication pay $149 for the initial weight-loss visit and $75 per follow-up, or use insurance, and buy the medication at their pharmacy.

Branded vs compounded

Compounded semaglutide and compounded tirzepatide, each as a weekly injection or a daily oral dissolving tablet, with B12 added to the semaglutide and niacinamide to the injectable tirzepatide. Compounded drugs are made by a pharmacy for an individual prescription and are not FDA-approved; the clinic says so plainly but doesn't name the compounding pharmacy, so ask if that matters to you. Brand-name Wegovy and Zepbound can be prescribed and sent to your local pharmacy, which is the route to use if your plan covers them; the clinic helps with prior authorization. Older oral options, including phentermine, Qsymia, Contrave and orlistat, are also available. A search of the FDA warning-letter database for Wholesome Clinic returned no letters.

Pros and watch-outs

The evidence behind what Wholesome Clinic prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• What the semaglutide weight-loss trials actually showed

  STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.

• Tirzepatide vs semaglutide for weight loss: what the trials actually support

  Most comparisons are cross-trial. Only SURPASS-2 and SURMOUNT-5 randomized one drug against the other — here's the precise distinction.

• Oral tirzepatide: the honest status of a pill that does not exist yet

  There is no FDA-approved oral tirzepatide. Here is why an oral peptide is hard, what the 'oral tirzepatide' sold online really is, and the oral incretins that actually exist.

• Compounded vs branded GLP-1: regulatory status, sourcing and the evidence

  Compounded GLP-1 isn't FDA-approved, the shortage exception behind it ended in 2025, the FDA moved against mass-marketed copies in 2026, and the trial data belong to the branded product. Here's the precise picture.

How Wholesome Clinic compares

A few alternatives worth a look, depending on what you’re optimizing for.

• Trimi Health

  Low-cost compounded GLP-1 with thorough dosing guidance

  See Trimi Health →
• Collective

  A low all-in GLP-1 cost, if you will actually keep the annual membership

  See Collective →
• JM Integrated Health

  People in one of its eight states who want the same clinician at every visit and are comfortable paying the pharmacy separately for medication

  See JM Integrated Health →

More GLP-1 telehealth reviews: Gaya Wellness · MaxLife · Medro · Mint Med · Mixx Health & Wellness · NavioMD