5-Amino-1MQ vs SLU-PP-332
Two novel small-molecule 'metabolism in a pill' compounds with elegant mouse mechanisms and the exact same problem — zero human trials of any kind.
5-Amino-1MQ
An NNMT inhibitor that reverses obesity in mice by sparing the NAD+ pool; the mechanism is plausible, but the human evidence is nonexistent.
Full 5-Amino-1MQ evidence reviewSLU-PP-332
A synthetic ERR agonist that reproduces exercise-like gene-expression changes in mice — a genuinely novel mechanism with zero human data of any kind; everything sold under this name is unregulated research material.
Full SLU-PP-332 evidence reviewSide by side
| 5-Amino-1MQ | SLU-PP-332 | |
|---|---|---|
| Marketed for | Fat loss, metabolism | 'Exercise mimetic', metabolic health |
| Evidence grade | Preclinical / minimal | Preclinical / minimal |
| Family | Immune / metabolic | Metabolic / AMPK |
| Key human source | Neelakantan, Biochem Pharmacol 2018 | ERR agonist mouse exercise mimicry, Nat Commun 2023 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
5-Amino-1MQ is an NNMT inhibitor that reverses obesity in mice by sparing the NAD+ pool — a plausible, well-characterized mechanism with genuinely nonexistent human evidence. SLU-PP-332 works differently, as a synthetic ERR agonist that reproduces exercise-like gene-expression changes in mice — equally novel, equally untested in people. Both are early-stage research chemicals sold as finished supplements years ahead of any human data.
5-Amino-1MQ fits if
The fat-loss/NNMT mechanism specifically is the interest, understanding this is unregulated research material with no human safety data.
SLU-PP-332 fits if
The 'exercise mimetic' mechanism specifically is the interest — same caveat: no human trials of any kind exist.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm 5-Amino-1MQ availability before ordering.
