5-Amino-1MQ vs Adipotide
Two fat-loss compounds that never reached approved human use. One has a clean mechanism and no data in people at all; the other has a dramatic primate result and a kidney-toxicity signal.
5-Amino-1MQ
An NNMT inhibitor that reverses obesity in mice by sparing the NAD+ pool; the mechanism is plausible, but the human evidence is nonexistent.
Full 5-Amino-1MQ evidence reviewAdipotide
FTPP
Destroyed white fat's blood supply and caused rapid weight loss in obese monkeys — but the same study found dose-dependent kidney toxicity, and it never reached approved human use.
Full Adipotide evidence reviewSide by side
| 5-Amino-1MQ | Adipotide | |
|---|---|---|
| Marketed for | Fat loss, metabolism | Rapid fat loss |
| Evidence grade | Preclinical / minimal | Preclinical / minimal |
| Family | Immune / metabolic | Immune / metabolic |
| Regulatory status | Not FDA-approved | Investigational |
| How it's obtained | Research-only | Research-only |
| Key human source | Neelakantan, Biochem Pharmacol 2018 | Barnhart, Sci Transl Med 2011 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
Neither has been studied in a registered human clinical trial, so neither has human efficacy, safety, dosing, or pharmacokinetic data. 5-Amino-1MQ is an NNMT inhibitor that reduced body weight and fat mass in diet-induced obese mice without reducing food intake by sparing the cellular NAD+ and methyl pool; the mechanism is plausible and every human claim attached to it is extrapolation. Adipotide went further in animals, producing rapid weight loss, marked white-fat reduction on imaging, and improved insulin resistance in obese rhesus monkeys, but the same study documented dose-dependent, treatment-related changes in renal proximal-tubule function, described as reversible at the doses tested and still a clear organ-toxicity signal. Adipotide is investigational, never advanced into approved human use, and both are sold as unregulated research chemicals.
5-Amino-1MQ fits if
5-Amino-1MQ is the one to watch if you follow NAD+ and methylation biology and want a mechanism that is interesting without a documented organ-toxicity flag.
Adipotide fits if
Adipotide is worth reading only as a cautionary case, where the most dramatic preclinical fat-loss result here came attached to kidney toxicity in the very same study.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm 5-Amino-1MQ availability before ordering.
