CLYR Health review

What it is

CLYR Health is run by Clyr Health, LLC. Its terms say clinical care comes through MD Integrations, a clinician network used by a number of telehealth brands, and that compounded prescriptions are filled by The Pharmacy Hub in Miami, Florida. CLYR itself isn't a pharmacy or a medical practice. Besides weight loss, it sells daily wellness products such as NAD⁺, sermorelin and glutathione, sexual-health tablets, a hair-loss tablet, and ivermectin and mebendazole capsules sold as antiparasitic protocols. Support is by email and contact form from 9 a.m. to 6 p.m. Eastern on weekdays and 10 a.m. to 2 p.m. on Saturdays. Its terms say the service is available only in certain states, without listing them, and disputes go to individual arbitration. The site displays a LegitScript seal.

How it works

You pick a medication and plan first, with the price on the page, then complete a questionnaire about your health history, current medications, height and weight, which takes about five minutes. A licensed provider reviews it, confirms whether the medication is appropriate and sets your starting dose. Checkout happens after the questionnaire. The pharmacy prepares compounded vials and ships them in a temperature-controlled box with syringes, usually within one to three business days of approval, and the outer box carries no product name. After that, you message your provider through the patient portal about side effects or timing, dose increases are decided with them, and you reorder from the portal when you get a low-supply email. If you're already on a GLP-1, you can choose your current dose or one step up instead of restarting, and the provider may ask for your current prescription. Missed appointments carry a $25 fee.

Pricing transparency

Every price includes the provider consultation, medication, supplies and shipping, billed once. Compounded semaglutide with glycine and B12 is $169 for a 28-day vial at 0.4 mg a week, $199 at 0.9 mg and $229 at 1.5 mg, or $304, $358 and $412 for two months in one box. Compounded tirzepatide with B6 is $149 for a starter month at 2.5 mg, or $269 for a two-month box that steps up to 5 mg; after that it's $249 a month at 5 mg, $299 at 10 mg and $329 at 12.5 mg, with two-month boxes at $449 to $499. Brand-name Foundayo and Wegovy tablets are $299 a month, and the Zepbound pen is $499 a month. As an example, a new semaglutide patient stepping through all three doses one month at a time would pay $169, $199 and $229, or $597 for the first three months. The product pages say nothing renews automatically, though the terms allow for subscriptions on some offerings, so check what you're signing up for at checkout. The site advertises a full refund if a provider finds treatment isn't appropriate, but its terms say an order can't be canceled once it's submitted for review and that all fees are non-refundable. Insurance isn't accepted.

Branded vs compounded

CLYR offers compounded semaglutide combined with glycine and vitamin B12, compounded tirzepatide combined with vitamin B6, and three brand-name options: Foundayo (orforglipron), Eli Lilly's daily oral GLP-1 tablet; Wegovy tablets, Novo Nordisk's oral semaglutide; and the Zepbound KwikPen. The brand-name drugs are FDA-approved and factory-sealed. The compounded versions are prepared by a state-licensed 503A pharmacy and are not FDA-approved, which the site states plainly. It also sells a lipotropic injection as a weight-loss add-on; that isn't a GLP-1. A search of the FDA warning-letter database under CLYR, Clyr Health and its web address returned no letters.

Pros and watch-outs

The evidence behind what CLYR Health prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• What the semaglutide weight-loss trials actually showed

  STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.

• Tirzepatide vs semaglutide for weight loss: what the trials actually support

  Most comparisons are cross-trial. Only SURPASS-2 and SURMOUNT-5 randomized one drug against the other — here's the precise distinction.

• Orforglipron: the oral non-peptide GLP-1, and what the trials actually show

  A once-daily small-molecule GLP-1 pill with no food restrictions — from Phase 2 proof of concept to the Phase 3 read-outs. The evidence, graded.

How CLYR Health compares

A few alternatives worth a look, depending on what you’re optimizing for.

• Peter MD

  GLP-1 from a men's-health provider that also covers TRT and longevity

  See Peter MD →
• MadeMed

  GLP-1 paired with NAD⁺ and sermorelin under one account

  See MadeMed →
• NavioMD

  Buyers who want a same-day live visit, no membership, and a choice of compounded tirzepatide or brand-name Zepbound

  See NavioMD →

More GLP-1 telehealth reviews: Blue Haven RX · Zealthy · Good Life Meds · Noom Med · Dollar Dad Club · MEDvidi