Immortals review

What it is

Immortals is a longevity telehealth platform founded by Bryan Johnson and Kate Tolo, with Dr. Carl Seger, MD, as its clinical lead, selling compounded semaglutide and tirzepatide in both personalized and microdose forms alongside a peptide and longevity line: sermorelin injections, NAD⁺ as an injection or nasal spray, glutathione as an injection or nasal spray, bremelanotide as an injection or nasal spray, a peptide skin complex, and a set of generics including metformin, acarbose, tretinoin and tadalafil. It is LegitScript certified, charges no membership fee, and describes prescriptions as filled by licensed US pharmacies.

How it works

A US-licensed, board-certified physician reviews your intake, typically within 72 hours, and everything after that — the prescription, unlimited follow-up by chat, video consults where offered — is bundled into the product price with no membership fee on top. The platform's own framing is "you pay for treatment, that's it", and the pricing structure bears that out. Two structural features are worth understanding before enrolling. Billing is quarterly with a three-month commitment paid up front, so there is no monthly option and the real decision is a quarterly one. And no state list is published: it says only that treatment is available to adults in eligible US states, with some states requiring a synchronous audio or video consultation before approval, so eligibility is confirmed at intake. Labs are not included and no baseline bloodwork protocol is described, which is the gap to note before a growth-hormone-axis peptide. Its pharmacies are described as licensed US facilities but none is named individually.

Pricing transparency

Published per molecule and per route, with both the promotional and the regular rate shown, which is the right way to do it. Sermorelin injections are from $119 a month promotional against $165 regular. NAD⁺ is $119 promotional against $175 regular for the injection and $101 against $140 for the nasal spray. Glutathione is $107 against $134 for the injection and $140 against $195 for the nasal spray. Bremelanotide is $73 against $92 for the injection and $151 against $210 for the nasal spray. On the GLP-1 side, semaglutide runs $167 microdose or $196 personalized, tirzepatide $180 or $255. Because the regular rate is displayed next to the promotional one, the figure to budget against is the higher one — a promotional price is what you pay to start, not what you pay to continue, and we have not treated the promotional figures as a price floor for that reason. Everything is billed quarterly with the three months paid up front, so the entry commitment is roughly three times the monthly figure.

Branded vs compounded

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. Immortals is LegitScript certified and describes its pharmacies as licensed US facilities without naming them, and compounded sterile products are not FDA-reviewed for purity and potency the way approved drugs are. On the evidence, this is the rare provider whose own copy does most of the work honestly. Its chief medical officer's quote on the sermorelin page states outright that sermorelin has never been tested in a clinical trial and that using it for weight management is experimental and off-label, correctly noting that it works through the same mechanism as tesamorelin — which does have approved human evidence, for HIV-associated lipodystrophy specifically rather than general wellness. That is precisely our reading. Injected and intranasal NAD⁺ have no controlled human outcome trials; the oral precursors NR and NMN are the studied forms and they raise blood NAD⁺, a biomarker rather than a demonstrated benefit. Glutathione by injection or nasal spray has essentially no controlled human outcome evidence. Bremelanotide is the outlier with genuine randomised human data, for hypoactive sexual desire disorder specifically, and the platform cites the published trials by name — the effect there is real but modest. Individual results vary.

Pros and watch-outs

The evidence behind what Immortals prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• Sermorelin: a real GHRH drug, read against the anti-aging pitch

  An approved growth-hormone-releasing analog with a pediatric track record — and a longevity case built more on biomarkers than outcomes.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

• Glutathione: the master antioxidant, and where the evidence actually is

  Oral glutathione really does raise your body stores (a 6-month RCT proved it) — but the longevity and detox claims are unproven, skin-lightening is modest, and IV glutathione is the most marketed, least evidenced route. The precursors may be the smarter bet.

• PT-141 (bremelanotide): the evidence on a research-popular peptide that is actually FDA-approved

  Bremelanotide (Vyleesi) is FDA-approved for HSDD in premenopausal women, with phase-3 trial evidence. A straight read of what's proven — and where off-label use goes beyond it.

How Immortals compares

A few alternatives worth a look, depending on what you’re optimizing for.

• CoreAge Rx

  Injected or intranasal NAD⁺ at a published price across 50 states

  See CoreAge Rx →
• SLSystem Labs

  NAD⁺ bundled with glutathione, B-12 and sermorelin from one service

  See System Labs →
• Live Vital

  Pairing a GLP-1 with a wider peptide and longevity protocol

  See Live Vital →