Our verdict
Lttl publishes a full price matrix before checkout.
Main trade-offs
- The "plans start at" headlines are 52-week prepay rates; per four-week supply is $149 for sermorelin and NAD⁺
- Four pharmacy partners are named, but the assigned dispenser is not disclosed before intake
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Compounded medicines are not FDA-approved. A licensed clinician must assess whether treatment is appropriate; availability does not establish safety or benefit.
Good fit
Shoppers who want every molecule and every commitment tier priced openly before intake, and who will budget against the per four-week supply rate rather than the headline.
Consider other options if
Anyone who needs a confirmed dispensing pharmacy, product-specific state availability or settled refund terms before intake.
Cost and care at a glance
- Category
- Peptide telehealth
- Published cost
- Sermorelin $149 for 4 weeks; $417 for 12, $774 for 24 or $1,188 for 52; refund terms conflict
- Insurance
- Cash-pay, no insurance
- Visit
- Async intake
- Availability
- 50 states and DC claimed; product access varies
- LegitScript
- Claimed by provider
Our review in detail
Full assessment
Lttl publishes a full price matrix before checkout. Sermorelin and the three NAD⁺ forms start at $149 for a four-week supply; longer supplies require 12-, 24- or 52-week prepayment. Its terms name four pharmacy partners and claim service across all 50 states plus DC, subject to product availability. The terms promise a full refund if a clinician finds you ineligible at intake, but other pages say a consultation fee may remain after review; medication refund cutoffs also conflict. Get the applicable charges and refund terms in writing.
What it is
Lttl (pronounced "little") is a direct-to-consumer telehealth brand owned and operated by The Commerce Group Holdings, LLC. Its weight-loss line covers compounded semaglutide and tirzepatide as injectables, an oral dissolving-tablet semaglutide, and a microdose line for both molecules. Its longevity line covers sermorelin, glutathione, methylene blue, MIC B12, L-carnitine, and NAD⁺ in three forms — injectable, nasal spray and oral liposomal liquid. A separate peptide program is announced as coming soon, with no prices yet. Clinical services are delivered by independent networks of US-licensed clinicians, and it bills one flat rate regardless of dose.
How care works
Lttl begins with an asynchronous assessment reviewed by a licensed clinician, then ships prescribed medication through a pharmacy partner. Its terms name RedRock Compounding Pharmacy, Health Warehouse, Precision Compounding Pharmacy and Triad Rx; they do not identify which will dispense a given order. The terms claim services across all 50 states and Washington DC while warning that particular services may be unavailable in some places. The published inclusions describe access to a care team and cold-chain shipping where needed, but an insurance page allows applicable consultation fees after review, so the exact final charge needs confirmation. The site states flat dose pricing. A banner promises prescription and shipping within 48 hours, while its shipping policy allows two to five business days to process plus three to seven to deliver. The footer displays a self-hosted LegitScript badge linked to a general lookup page.
Costs, billing and cancellation
The matrix prices 4-, 12-, 24- and 52-week supplies, not equal calendar-month blocks. Sermorelin and the injectable, nasal and oral NAD⁺ forms are $149 for four weeks; 12 weeks cost $417 ($139 per four weeks) and 24 weeks cost $774 ($129 per four weeks). The 52-week supply costs $1,188 up front and is advertised as $99 monthly, not $99 per four weeks. Glutathione, MIC B12, L-carnitine and methylene blue start at $119 for four weeks, with lower prepaid equivalents. The separate $99 sermorelin/NAD⁺ and $89 other-product introductory offers apply to the first four-week supply only. Flat dose pricing is advertised. The terms promise a full refund when an initial clinician review finds a patient ineligible, while the returns and insurance pages say consultation fees may be nonrefundable after review. The terms make medication nonrefundable after intake submission, but the returns page names pharmacy shipment as the cutoff. Confirm the applicable fee, renewal cadence and refund trigger before paying.
Medication and evidence
Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. Lttl's own FAQ is unusually blunt — its compounded products are produced in FDA-registered facilities but are not FDA-approved and have not been evaluated by the FDA for safety, efficacy or quality — and its terms name RedRock, Health Warehouse, Precision and Triad Rx as possible partners without assigning a specific dispenser, so compounded sterile products carry the usual caveat that the FDA does not review them for purity and potency. On evidence the longevity ladder is a mix. Sermorelin is a GHRH analog that stimulates your own pituitary; the mechanism is real and well described, and the long-term human outcome data is thin. NAD⁺ deserves particular care here because Lttl sells three routes: injected, intranasal and oral liposomal NAD⁺ all lack controlled human outcome trials, and the intranasal and liposomal routes have the weakest pharmacokinetic support of the three — the NAD⁺ forms with human trial data are the oral precursors NR and NMN, and what those trials show is a raised blood NAD⁺ level rather than a clinical benefit. Injectable glutathione has essentially no controlled human outcome data. Methylene blue is a genuinely approved drug for methemoglobinemia being sold here for cognitive and mitochondrial claims that have no controlled human outcome trials behind them, and it interacts seriously with serotonergic medications including SSRIs — a question to raise explicitly at intake. Individual results vary.
Sources checked October 26, 2026
Pros and watch-outs
What we like
- Publishes the full price matrix — every molecule, form and commitment length — before checkout
- Flat dose pricing stated verbatim as "same price at every dose", so a dose increase does not raise the bill
- States plainly that its compounded products are not FDA-approved and have not been evaluated by the FDA
- Itemizes inclusions, including cold-chain shipping with tracking where required
- Cancel a subscription anytime, with the terms promising a full refund if a provider finds you medically ineligible at intake
Watch-outs
- The "plans start at" headlines are 52-week prepay rates; per four-week supply is $149 for sermorelin and NAD⁺
- Four pharmacy partners are named, but the assigned dispenser is not disclosed before intake
- The terms claim service in 50 states and DC but do not establish product-specific eligibility
- The footer's "LegitScript Certified" badge is a self-hosted image, not a seal issued by LegitScript
- A banner promises prescription and shipping within 48 hours while the shipping policy states 2–5 days to process plus 3–7 to deliver
Best for
Shoppers who want every molecule and every commitment tier priced openly before intake, and who will budget against the per four-week supply rate rather than the headline.
Who should look elsewhere
Anyone who needs a confirmed dispensing pharmacy, product-specific state availability or settled refund terms before intake.
Research relevant to Lttl
Explore the evidence and its limits. Findings apply to the formulation, route and population studied; they do not establish the quality or effectiveness of a provider’s products.
- Sermorelin benefits: does it work? What the trials show
A real GHRH drug, read against the anti-aging pitch: an approved growth-hormone-releasing analog with a pediatric track record, and a longevity case built more on biomarkers than outcomes.
- NAD+ precursors (NR and NMN): what the human trials actually show
They raise NAD+ and look safe short-term, but human evidence is surrogate-marker level, and no trial shows they extend healthspan.
- Glutathione: the master antioxidant, and where the evidence actually is
Oral glutathione really does raise your body stores (a 6-month RCT proved it) — but the longevity and detox claims are unproven, skin-lightening is modest, and IV glutathione is the most marketed, least evidenced route. The precursors may be the smarter bet.
How Lttl compares
A few alternatives worth a look, depending on what you’re optimizing for.
- Live Vital
A wide growth-hormone-axis and research-peptide menu
See Live Vital → - System Labs
Sermorelin alongside NAD⁺, glutathione and B-12 from one service
See System Labs →
KongoA published one-month NAD⁺ injection charge without a membership fee
See Kongo →
More peptide telehealth reviews: RxSpan MDTelos RXDefy MedicalInvigor MedicalAgelessRx10rx
Pharmacology & mechanisms
How we assessed this. This review reflects Aminoscope’s own read of Lttl’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- When is sermorelin advertised at $99?
- The $99 introductory offer covers the first four-week supply only. Lttl also advertises $99 monthly on a 52-week plan, but that plan costs $1,188 up front; it is not a $99 four-week charge. Otherwise four weeks cost $149, 12 weeks $417 and 24 weeks $774. Confirm the next debit and cadence before ordering.
- What does NAD⁺ cost, and which form should I pick?
- Injectable, nasal and oral liquid NAD⁺ are each $149 for a four-week supply. The 52-week plan costs $1,188 up front and is advertised as $99 monthly, not $99 per four weeks. A separate $99 first-four-week offer is introductory only. None of the three routes has controlled human outcome trials; oral precursors NR and NMN raise blood NAD⁺ rather than demonstrating a clinical outcome.
- Is Lttl LegitScript-certified?
- It says so: the footer shows a "LegitScript Certified" badge. The badge is an image hosted on Lttl's own site and links to LegitScript's general lookup page rather than being a seal issued by LegitScript, so check the lookup yourself before relying on it.
- Is methylene blue safe to take with an antidepressant?
- That is a question for a clinician before you order. Methylene blue is an approved drug for methemoglobinemia being sold here for cognitive and mitochondrial claims that have no controlled human outcome trials behind them, and it has a serious interaction with serotonergic medications including SSRIs. Raise every medication you take at intake.
- Is Lttl expensive compared with other peptide telehealth providers?
- Lttl publishes a starting figure of $149/mo. Across the 75 peptide telehealth providers we review that publish a single monthly figure, those run $49 to $349 with a median of $189, which puts Lttl below the median, toward the cheaper end. The other 142 peptide telehealth providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.
