Optimized Health review

What it is

Optimized Health is a LegitScript-certified concierge weight-loss and hormone clinic in Joplin, Missouri, led by Mathew Hammons, PA-C, with registered nurses on staff. It runs eight service lines: medical weight loss with GLP-1 medications, testosterone therapy for men at $175/mo including labs, bioidentical hormone therapy for women at $125/mo, peptide therapy from $225 per protocol, IV therapy across 14 formulations from $60 to $195, plus laser hair removal, skin resurfacing and body contouring. NAD⁺ and glutathione are sold as intramuscular add-on shots to any drip.

How it works

Hybrid, and the NAD⁺ half is in-person. Its telehealth arm covers Missouri, Iowa, Kansas, Utah and Washington, but the IV and IM menu is described as available in-clinic, administered by a registered nurse, with walk-ins welcome. That is worth naming plainly because most of this board ships vials for self-injection: here a nurse gives you the shot and you leave. The clinic publishes its entire price list — every drip, every add-on — with the stated position that there are no hidden fees, and it is cash-pay with HSA/FSA accepted. Its own explanation for offering NAD⁺ and glutathione as IM injections rather than only as drips is that both have very poor oral bioavailability, which is a fair statement of the pharmacology and also, notably, an argument about absorption rather than about outcomes. What you do not get is a named compounding source for the injectables or any published detail on the milligram dose in a $25 shot, and that dose is the single variable that would let you compare it against anything else.

Pricing transparency

Genuinely transparent, and structured differently from everything else on this board. NAD⁺ is a $25 intramuscular injection and glutathione a $15 intramuscular shot, both sold as add-ons to any IV drip; drips themselves run $60 for basic hydration to $195 for the largest recovery formulation, with the most-ordered options in the $125 to $135 range. There is no membership, no consultation fee for the IV line and no subscription. We publish no monthly floor for it because there is no month: the price is per session, and how it compares to a $129 or $199 monthly telehealth plan depends entirely on how often you go and how many milligrams you get, neither of which the site states. On the clinic's other lines, GLP-1 programs start at $200/mo for semaglutide and $250/mo for tirzepatide, testosterone is $175/mo with labs included, and peptide protocols start at $225 — but none of those is an NAD⁺ price and none should be read as one. Ask for the milligram dose per shot before comparing anything.

Branded vs compounded

Prescription and clinician-supervised, with a licensed provider deciding whether treatment is appropriate. The clinic does not name a compounding source for its injectables, and compounded sterile products are not reviewed by the FDA for purity and potency the way approved drugs are. On the evidence, this is a case where cost and evidence point in different directions. Intramuscular and intravenous NAD⁺ have no controlled human outcome trials at all; the one human intravenous study was a pharmacokinetic pilot that found infused NAD⁺ clears from plasma quickly. The NAD⁺ forms with human trial data are the oral precursors NR and NMN, and what those trials demonstrate is a reliably raised blood NAD⁺ level — a biomarker, not a clinical outcome. Injectable glutathione has essentially no controlled human outcome data behind the detoxification and skin claims made for it. A $25 price does not change the evidence tier; it changes what you risk to find out. Individual results vary.

Pros and watch-outs

The evidence behind what Optimized Health prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

• NAD+ IV therapy: an expensive drip ahead of its evidence

  Clinics sell NAD+ infusions for anti-aging, energy and addiction at $250–$1,500 a session — but there's no controlled trial of IV NAD+, and the real human evidence is for oral precursors, not the drip.

• Glutathione: the master antioxidant, and where the evidence actually is

  Oral glutathione really does raise your body stores (a 6-month RCT proved it) — but the longevity and detox claims are unproven, skin-lightening is modest, and IV glutathione is the most marketed, least evidenced route. The precursors may be the smarter bet.

How Optimized Health compares

A few alternatives worth a look, depending on what you’re optimizing for.

• OMOptions Medical Weight Loss

  NAD⁺ at a single published monthly price inside an established clinical brand

  See Options Medical Weight Loss →
• RERegenCen

  Patients in Michigan, Florida or the South Carolina Lowcountry who want NAD⁺ inside supervised hormone care

  See RegenCen →
• PTPrecision Telemed

  NAD⁺ from a platform whose prescribers and pharmacies you can independently verify

  See Precision Telemed →