Optimized Health review

Optimized Health prices NAD⁺ at $25 for an intramuscular shot and glutathione at $15, published openly on its IV therapy page with no membership and no hidden fees. That is not a cheaper version of a telehealth NAD⁺ subscription; it is a different purchase, and the comparison only works per dose. If you live near Joplin, Missouri and want to try an NAD⁺ injection without committing to a shipping cadence, this is about as low-friction and low-cost as the category gets. If you want NAD⁺ mailed to you, this is not that service.

Optimized Health is a concierge weight-loss and hormone clinic in Joplin, Missouri, led by Mathew Hammons, PA-C, with registered nurses on staff. It runs eight service lines: medical weight loss with GLP-1 medications, testosterone therapy for men at $175/mo including labs, bioidentical hormone therapy for women at $125/mo, peptide therapy from $225 per protocol, IV therapy across 14 formulations from $60 to $195, plus laser hair removal, skin resurfacing and body contouring. NAD⁺ and glutathione are sold as intramuscular add-on shots to any drip.

Hybrid, and the NAD⁺ half is in-person. Its telehealth arm covers Missouri, Iowa, Kansas, Utah and Washington, but the IV and IM menu is described as available in-clinic, administered by a registered nurse, with walk-ins welcome. That is worth naming plainly: there is no vial for self-injection, because a nurse gives you the shot and you leave. The clinic publishes its entire price list — every drip, every add-on — with the stated position that there are no hidden fees, and it is cash-pay with HSA/FSA accepted. Its own explanation for offering NAD⁺ and glutathione as IM injections rather than only as drips is that both have very poor oral bioavailability, which is a fair statement of the pharmacology and also, notably, an argument about absorption rather than about outcomes. What you do not get is a named compounding source for the injectables (the site says only that a licensed compounding pharmacy prepares the NAD⁺ and glutathione shots) or any published detail on the milligram dose in a $25 shot, and that dose is the single variable that would let you compare it against anything else.

Genuinely transparent, and structured differently from a monthly telehealth plan. NAD⁺ is a $25 intramuscular injection and glutathione a $15 intramuscular shot, both sold as add-ons to any IV drip; drips themselves run $60 for basic hydration to $195 for the largest recovery formulation, with the most-ordered options in the $125 to $135 range. There is no membership, no consultation fee for the IV line and no subscription. There is no monthly figure because there is no month: the price is per session, and how it compares to a $129 or $199 monthly telehealth plan depends entirely on how often you go and how many milligrams you get, neither of which the site states. On the clinic's other lines, GLP-1 programs start at $200/mo for semaglutide and $250/mo for tirzepatide, testosterone is $175/mo with labs included, and peptide protocols start at $225 — but none of those is an NAD⁺ price and none should be read as one. Ask for the milligram dose per shot before comparing anything.

Prescription and clinician-supervised, with a licensed provider deciding whether treatment is appropriate. The clinic does not name a compounding source for its injectables, and compounded sterile products are not reviewed by the FDA for purity and potency the way approved drugs are. On the evidence, this is a case where cost and evidence point in different directions. Intramuscular and intravenous NAD⁺ have no controlled human outcome trials at all; the one human intravenous study was a pharmacokinetic pilot that found infused NAD⁺ clears from plasma quickly. The NAD⁺ forms with human trial data are the oral precursors NR and NMN, and what those trials demonstrate is a reliably raised blood NAD⁺ level — a biomarker, not a clinical outcome. Injectable glutathione has essentially no controlled human outcome data behind the detoxification and skin claims made for it. A $25 price does not change the evidence tier; it changes what you risk to find out. Individual results vary.