Polly review
All-inclusive compounded, month to month
Compounded semaglutide at $179 a month and tirzepatide at $279 month to month, with consultation, medication and overnight shipping included. All 50 states, no membership fee.
Our verdict
Polly sells compounded semaglutide and tirzepatide at a flat month-to-month price that covers everything: the provider consultation, the medication at any dose, supplies and overnight shipping. At $179 a month for semaglutide and $279 for tirzepatide, with no membership fee, the monthly plan is easy to compare, and the 3- and 6-month plans drop to $135 and $199 a month if you'll prepay. It also offers sermorelin, NAD⁺ and lipotropic injections. The weak spots are transparency and flexibility. The site doesn't name the medical practice behind its providers and names only one pharmacy, prices sit in the help center rather than on the homepage, and once an order enters processing it can't be canceled. Ending a prepaid plan early also cancels its discount.
Disclosure: Aminoscope is reader-supported. Some links below are affiliate links — if you start care through them we may earn a commission, at no extra cost to you. Partners are listed first; a commission never changes what we write about a provider. How we make money.
At a glance
- Category
- GLP-1 telehealth
- Access
- Compounded semaglutide $179/mo, tirzepatide $279/mo month to month, all-inclusive
- Medications
- Compounded semaglutide · Compounded tirzepatide
- Insurance
- Cash-pay, no insurance
- Visit
- Quiz intake / Async intake
- Availability
- All 50 states
- LegitScript
- Claimed by provider
Partner alternative
yourEra
A low-cost entry point into compounded GLP-1 treatment
Check yourEra availability →What it is
Polly is a telehealth platform that connects patients with independent licensed providers and with licensed partner pharmacies; it doesn't provide medical care itself, and its terms say it is controlled from offices in Florida. Its main focus is weight loss with compounded GLP-1s, and it is expanding into healthy aging, menopause and longevity care, with sermorelin, NAD⁺ (as an injection or nasal spray) and a lipotropic MIC plus B12 injection on the menu. Prescriptions are filled by U.S. 503A compounding pharmacies; the help center names Hallandale Pharmacy as one partner and says the pharmacy can vary with the medication and your location. The site says care is available in all 50 states through providers licensed where you live. Polly doesn't accept insurance and isn't enrolled in Medicare or Medicaid. It displays a LegitScript seal.
How it works
You start with an online medical intake covering your health history, lifestyle and goals. An independent licensed provider reviews it to decide whether treatment is safe and appropriate and, if it is, writes a prescription that goes to a partner pharmacy. Medication generally ships within two to four business days after approval and pharmacy preparation, by free overnight delivery, Monday to Friday only. Your patient portal holds your treatment plan, messages with your care team and provider, refill dates, shipment tracking and a medication-level tracker. The provider can adjust your dose over time, and the help center explains how prior GLP-1 use and gaps in treatment are reviewed if you're switching from another service. If the provider finds you medically ineligible, the order is canceled and fully refunded.
Pricing transparency
Compounded semaglutide is $179 a month on a month-to-month plan, $166 a month on a 3-month plan and $135 a month on a 6-month plan. Compounded tirzepatide is $279 a month month to month, $216 a month for three months and $199 a month for six. The price includes the provider consultation, prescription, medication, supplies, overnight shipping and ongoing care-team support, with no membership fee, and it stays the same when your dose increases. The 3- and 6-month plans are billed up front, for example $1,194 for six months of tirzepatide, and the full supply ships at once. They aren't refundable after the first month, and ending one early reverts the months already shipped to the standard monthly price. To stop a monthly plan, you email the care team or use the portal before the next order enters processing; your plan runs to the end of the billing cycle with no prorated refunds. Orders can't be canceled once the prescription reaches the pharmacy. HSA and FSA cards, Klarna, Affirm, Afterpay, Apple Pay and Google Pay are accepted, with some limits on recurring payments.
Branded vs compounded
Compounded semaglutide and compounded tirzepatide as weekly injections, with some pharmacy formulations including B12 or glycine. Polly states that compounded medications are not individually approved by the FDA; they are prepared for each patient by state-licensed compounding pharmacies. There are no brand-name GLP-1s and no oral versions. Outside weight loss, Polly sells sermorelin, NAD⁺ and a lipotropic MIC plus B12 injection, which are also compounded. A search of the FDA warning-letter database for Polly's company and web address returned no letters.
Pros and watch-outs
What we like
- Month-to-month semaglutide at $179, all-inclusive
- Same price at every dose, no membership fee
- Prepaid plans from $135 a month for semaglutide
- Full refund if a provider finds you ineligible
- All 50 states; displays a LegitScript seal
Watch-outs
- Medical practice behind its providers isn't named
- Only one pharmacy partner is named
- Orders can't be canceled once processing starts
- Ending a prepaid plan early cancels the discount
- Compounded only; no brand-name or insurance route
Best for
Cash-pay buyers who want a simple, all-inclusive monthly price on compounded semaglutide or tirzepatide with fast shipping and no membership.
Who should look elsewhere
Anyone who wants to know the prescribing practice and pharmacy up front, needs a brand-name drug or insurance, or wants flexibility to cancel a prepaid plan.
The evidence behind what Polly prescribes
We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.
- What the semaglutide weight-loss trials actually showed
STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.
- Tirzepatide vs semaglutide for weight loss: what the trials actually support
Most comparisons are cross-trial. Only SURPASS-2 and SURMOUNT-5 randomized one drug against the other — here's the precise distinction.
- Compounded vs branded GLP-1: regulatory status, sourcing and the evidence
Compounded GLP-1 isn't FDA-approved, the shortage exception behind it ended in 2025, the FDA moved against mass-marketed copies in 2026, and the trial data belong to the branded product. Here's the precise picture.
How Polly compares
A few alternatives worth a look, depending on what you’re optimizing for.
CoreAge RxFlat pricing that does not climb as your dose titrates up
See CoreAge Rx →- Oak Longevity
Low-cost compounded GLP-1 bundled with a longevity stack
See Oak Longevity → 
Ondra HealthCash-pay buyers who want a low month-to-month compounded price, a choice of named pharmacies and the same price at every dose
See Ondra Health →
More GLP-1 telehealth reviews: WellMedRxSprout HealthWellorithmTrimRxaltRxFridays
Research & data
How we assessed this. This review reflects Aminoscope’s own read of Polly’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- How much does Polly cost?
- Compounded semaglutide is $179 a month month to month, or $166 and $135 a month on 3- and 6-month plans. Compounded tirzepatide is $279 a month, or $216 and $199 on longer plans. The consultation, medication, supplies and shipping are included.
- Does Polly charge a membership fee?
- No. Polly says there are no membership or consultation fees, and the plan price stays the same if your dose changes.
- Can I cancel Polly?
- Yes, by email or through the portal before your next order enters processing. Your plan stays active to the end of the billing cycle, with no prorated refund. Prepaid 3- and 6-month plans aren't refundable after the first month.
- What else does Polly offer besides GLP-1s?
- Sermorelin, NAD⁺ as an injection or nasal spray, and a lipotropic MIC plus B12 injection, all compounded and prescribed by independent providers.
- Does Polly take insurance?
- No. Polly is self-pay only and doesn't bill insurance, Medicare or Medicaid. HSA and FSA cards can be used, and the 3- and 6-month plans can be split into installments with Klarna, Affirm or Afterpay; those services don't work for month-to-month recurring charges.
- Is Polly legit?
- Polly is a GLP-1 telehealth service you reach through an online questionnaire and an online intake a clinician reviews. The medications it names are Compounded semaglutide and Compounded tirzepatide. Its stated availability: All 50 states. What it publishes up front: Compounded semaglutide $179/mo, tirzepatide $279/mo month to month, all-inclusive. It is cash-pay and states it does not bill insurance. It shows a LegitScript seal. Ask the company for its certificate number before you rely on it. Those are the provider's own published claims rather than checks we could run ourselves, so get the ones that matter to you confirmed in writing before you pay.
- Is Polly expensive compared with other GLP-1 telehealth providers?
- Polly publishes a starting figure of $179/mo. Across the 87 GLP-1 telehealth providers we review that publish a single monthly figure, those run $49 to $399 with a median of $190, which puts Polly below the median, toward the cheaper end. The other 101 GLP-1 telehealth providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.