Oak Longevity review

What it is

Oak Longevity is a cash-pay telehealth platform run by Oak Longevity Holdings Corp. (its terms name Leaf Longevity Holdings Corp., doing business as Oak Longevity). It sells compounded semaglutide and compounded tirzepatide as weekly injections, with B6 or B12 added when appropriate, and non-injectable semaglutide as under-the-tongue drops or tablets. Its GLP-1 page also lists branded GLP-1 injector pens and the oral Wegovy tablet. Beyond weight loss it treats erectile dysfunction, hair loss and skin, offers hormone therapy for women, and runs a longevity line of NAD⁺ injections, sermorelin and tesamorelin. Oak describes itself as a facilitator connecting you with contracted physicians and pharmacies rather than a medical practice, and it displays a LegitScript certification seal.

How it works

Oak's process is short. You answer a quick online questionnaire, which Oak says takes about 60 seconds, a licensed provider reviews it with no video call required, and approval can come the same day. Medication ships free with tracking, and Oak says it ships the same day. After that you can message the care team and a provider about side effects or dose changes, with free health coaching and round-the-clock support advertised. Oak says its providers are board-certified and licensed in all 50 states. Its stated eligibility rules exclude people under 18, people who are pregnant or nursing, and anyone with a BMI under 22 and no related health conditions. It does not name the pharmacies that fill its prescriptions; the terms say only that Oak has contracts with various pharmacies. The quiz begins by asking how much weight you want to lose, and Oak's own instructions say you enroll in a plan and check out before you complete the medical questionnaire. That puts payment ahead of the provider's decision, so check how a refund works if you aren't approved.

Pricing transparency

Oak gives two different starting prices. The homepage banner and GLP-1 tile say "from $89/mo," with no detail on which drug or plan that applies to. The weight-loss page says "Oak's weight loss programs start at $190/month," and its comparison table repeats $190. Neither page lists a price per drug or per dose, so the real figure for compounded semaglutide versus tirzepatide, or for a higher dose, appears only at checkout. Oak advertises no hidden membership fees, no surprise charges and free shipping, and it accepts FSA and HSA cards; it does not take insurance. Its terms of use add detail the sales pages leave out. The checkout charge includes a membership fee for the provider consult. Many prescriptions ship as packages holding several weeks of medication on a subscription that renews automatically. And the subscription price can change with your dose, prescription or form of medication. You cancel from your current-prescription page. Once a provider has approved your treatment and the order has gone to the pharmacy, it can't be canceled and won't be refunded, even if you cancel your account or try to stop the shipment. The longevity line is priced separately: NAD⁺ is $175 a month (regularly $199), and sermorelin and tesamorelin are priced after the assessment.

Branded vs compounded

Compounded semaglutide and compounded tirzepatide by weekly injection, and semaglutide as sublingual drops or tablets. Oak's GLP-1 page also lists branded injector pens and the Wegovy pill, though it doesn't price them. The compounded products are not FDA-approved, which Oak's footer says. Its FAQ goes further than the evidence when it calls them "Same science, fraction of the price": the trial results belong to the branded drugs, the FDA doesn't test compounded versions for potency or purity, and under-the-tongue semaglutide has no approved counterpart at all. The longevity line is a separate decision. Injected NAD⁺ has no controlled human outcome trials. Sermorelin raises growth-hormone output, but evidence for the sleep and recovery benefits the site lists is thin. Tesamorelin, as Oak's own research summary notes, is FDA-approved to reduce abdominal fat in adults living with HIV, not for general body composition.

Pros and watch-outs

The evidence behind what Oak Longevity prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• What the semaglutide weight-loss trials actually showed

  STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.

• SURMOUNT-1 explained: the trial that made tirzepatide the benchmark

  The landmark phase 3 trial of tirzepatide for obesity — the design, the up-to-20.9% weight loss, the safety profile, and the limits of what it proved.

• Oral semaglutide (Rybelsus): what the PIONEER trials actually showed

  A GLP-1 peptide in a pill is hard to pull off. PIONEER 1, 4, and 6 plus OASIS 1 — read straight from the primary literature.

How Oak Longevity compares

A few alternatives worth a look, depending on what you’re optimizing for.

• HEHealthRX

  Low-cost compounded GLP-1 with overnight shipping and physician review

  See HealthRX →
• Enhance MD

  Lab-guided treatment under ongoing physician oversight

  See Enhance MD →
• Bodybuilding Health+

  GLP-1 alongside NAD⁺ and sermorelin from a fitness brand

  See Bodybuilding Health+ →

More GLP-1 telehealth reviews: Revive Meds · Rivas Medical Weight Loss · Bon Health · Cabana · CaliberRx · Call-On-Doc