Rylo Health review

Rylo Health makes itself easy to check. It names its dispensing pharmacy in full (VialsRX at 6220 Westpark Dr, Houston, Texas, with a phone number), its medical group (Lone Star Virtual Health PLLC) and two of its physicians, and it displays a LegitScript seal. Its pricing is honest once you flip a toggle. Every product page opens on the quarterly rate, and a Monthly button shows what you pay if you want to be free to stop: sermorelin is $183 a month billed $549 a quarter, or $249 month to month; NAD⁺ is $183 or $219; glutathione is $133 or $149. Plan around the second number. The gaps are the dose behind each price and a set of terms of service the company itself says is still being drafted.

Rylo Health (Rylo Health LLC, based in Katy, Texas) is a telehealth platform selling five compounded medications: tirzepatide and semaglutide for weight loss, and NAD⁺, sermorelin and glutathione as at-home injection protocols. Sermorelin is described as a nightly peptide that prompts the pituitary to release its own growth hormone. NAD⁺ is compounded at 100 mg/mL for injection under the skin and pitched for cellular energy. Glutathione is pitched for antioxidant, liver and skin support. Clinical care is stated to run through Lone Star Virtual Health PLLC, with licensed physicians in all fifty states, and the About page names two of them: Abhishek Patel, DO, and Asad Niazi, MD, MPH. Prescriptions are filled by VialsRX in Houston, and Rylo states that it never handles or dispenses medication itself.

A short online questionnaire (about five minutes, with no video call and no lab work), a physician review stated to happen within 24 hours, and free two-day shipping in insulated packaging with a cold pack if you are prescribed. Each price is stated to include the medication, syringes and injection supplies, the physician review and shipping, and the care team is reached by text rather than a chatbot. The disclosure is the strong part. A pharmacy with a full street address and a phone number is one you can call and ask about a batch; "a US-licensed compounding pharmacy" is not. A medical group with a PLLC suffix is a registered entity you can look up, and two named physicians with their credentials are more than most telehealth brands give you. Rylo also says every batch is tested for sterility, endotoxin and potency before it ships; that is a reasonable claim for a 503A pharmacy, but no certificate of analysis is posted for you to read. Cancellation is plain: no contracts, no cancellation fee, cancel from the patient portal or by messaging support, and the current month's shipment still goes out. The refund policy is short and clear. Starting is free and fully refundable until your first physician consultation, and fees are refunded if you are found medically ineligible. Once a medication is compounded or shipped it is generally non-refundable, a damaged, defective or wrong order is replaced or refunded if you report it within 7 days, and approved refunds take 5 to 10 business days. The weak spot is the rest of the paperwork. The Terms of Service page is dated April 28, 2026 and says the full terms are "being drafted by our legal team", and its short summary mentions membership fees for platform access, which sits awkwardly beside the "no membership fee" promise on every product page. Ask which fees apply before you pay.

Every product page has a Monthly / Quarterly toggle, and it opens on Quarterly. Sermorelin shows $183 a month, billed $549 every three months; switch to Monthly and it is $249, with "No contract, cancel any month." NAD⁺ is $183 a month on the quarterly plan or $219 month to month, and glutathione is $133 (billed $399 a quarter) or $149. The weight-loss side works the same way: semaglutide is $100 a month billed $299 a quarter, or $139 month to month, and tirzepatide is $160 a month billed $479 a quarter, or $229 month to month, each at one price at every dose. The quarterly plan is a real saving, about $66 a month on sermorelin, if you are sure you will stay three months. The monthly rate is the price of being able to stop, so that is the one to compare. Note that the homepage FAQ says plans are "billed once every three months"; that describes the default, not the only option. What no page states is the dose, vial size or injection schedule behind a peptide price, so ask what a month of sermorelin or NAD⁺ actually contains before you compare it with another service's figure.

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. The dispensing pharmacy is named, which is the disclosure that matters most for an injectable, and compounded sterile products are still not reviewed by the FDA for purity and potency the way approved drugs are. On the evidence, the three longevity products sit on three different tiers. Sermorelin is a GHRH analog acting on a real, well-characterized growth-hormone axis, with human outcome data that thins out quickly past short-term IGF-1 movement. Injected NAD⁺ has no controlled human outcome trials at all — the one human intravenous study was a pharmacokinetic pilot showing infused NAD⁺ clears plasma quickly — while the NAD⁺ forms with human trial data are the oral precursors NR and NMN, which raise a blood level rather than demonstrate an outcome. Rylo's own NAD⁺ page is candid about this, calling NAD⁺ injection therapy experimental and its human evidence limited. Injectable glutathione has essentially no controlled human outcome data behind the antioxidant, detox and skin claims attached to it, and Rylo's glutathione page notes that the FDA has warned about injectable glutathione from unregulated sources. Individual results vary.