Our verdict
Signos+ combines compounded semaglutide or tirzepatide with an app, clinician support and periodic glucose sensors. The $199 monthly headline refers to three- or six-month programs, and included sensors do not cover continuous wear throughout either term. Auto-renewal, refill check-ins and separate cancellation rules deserve attention. Louisiana is excluded, and clinical eligibility applies.
Main trade-offs
- Compounded drugs are not FDA-approved
- Included sensors provide intermittent coverage
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Compounded medicines are not FDA-approved. A licensed clinician must assess whether treatment is appropriate; availability does not establish safety or benefit.
Good fit
Eligible adults interested in periodic glucose feedback and ongoing logging who can commit to the treatment term and discuss compounded medication with the prescriber.
Consider other options if
Patients seeking FDA-approved branded treatment, continuous sensor coverage included for the entire term, or unrestricted monthly cancellation.
Cost and care at a glance
- Category
- GLP-1 telehealth
- Published cost
- From $199/mo headline for 3- or 6-month terms; limited sensors; verify full term and renewal; Louisiana excluded
- Medications
- Compounded semaglutide · Compounded tirzepatide
- Insurance
- Cash-pay, no insurance
- Availability
- 49 states and DC; Louisiana excluded; generally ages 18–74, Nebraska 19+
Our review in detail
Full assessment
Signos+ has a clear purpose for someone who wants glucose feedback alongside prescription weight care: combine the medicine, an app and selected periods of sensor wear in one program. Its appeal depends on actually wanting to use that information. The included sensors are a limited allocation, so this is not continuous sensor coverage for the whole three- or six-month term. All advertised Signos+ medicines are compounded, despite the separate FDA clearance associated with its monitoring system. That distinction is central to assessing the offer. We would consider it for an eligible adult interested in structured logging and nutrition support who understands both the treatment risks and the term commitment. The website’s testimonials and internal success figures do not establish that this combination produces better long-term outcomes than another care model.
What it is
Signos provides the technology and wellness experience, while OpenLoop Health and independent licensed clinicians provide the medical care. The landing page identifies compounded semaglutide and tirzepatide as the available Signos+ treatments. Its monitoring system is described for adults who are not using insulin, and its instructions say not to make medication changes from sensor readings without consulting a qualified professional. A glucose trace can start a discussion about a meal or activity pattern; it cannot independently decide the right prescription dose. General program eligibility is ages 18 through 74, with a minimum age of 19 in Nebraska. Louisiana is excluded. Some states require a video visit during intake. Those restrictions should be resolved before treating a short online quiz as an enrollment approval.
How care works
The Signos+ help center gives a more practical account of the bundle than a broad promise of round-the-clock glucose insights. A three-month term includes two 15-day Stelo sensors; a six-month term includes four. The program recommends targeted periods of wear, such as near the beginning and end, with extra two-packs advertised at $99 for people seeking more monitoring. Compare the included wear time with how often you personally expect to use a sensor. The app supports meal and activity logging, medication tracking and wellness check-ins. Monthly check-ins help clinicians assess progress and release future medication shipments. The help article distinguishes medical support from app or account support, listing a clinical contact available seven days a week between 8 a.m. and 8 p.m. Eastern. That is a useful separation: a billing representative cannot resolve a dosing concern. Ask where nutrition support ends and clinical decision-making begins, especially when a glucose reading causes concern or symptoms do not match the device.
Costs, billing and cancellation
The starting $199 monthly figure accompanies three- or six-month programs. It should be read as a term offer until the exact payment schedule, total obligation and renewal amount are provided. Monthly medication shipments do not establish a cancel-any-month purchase. The support page says canceling renewal leaves remaining payments for the existing term due and does not create a prorated refund. The general subscription section allows app cancellation before term end, while the pharmaceutical section requires at least 72 hours before the billing date; a late request can result in another charge. Ask which instructions apply to each part of the combined order and obtain written confirmation that renewal is off. Initial medical ineligibility qualifies for a full refund, while other pharmaceutical refunds are restricted and later disqualification has its own conditions. The help center also warns that missed refill check-ins do not qualify for refunds. For a person unsure about continuing treatment, these obligations matter more than the monthly headline. Signos says it does not accept insurance. HSA or FSA reimbursement depends on the account administrator and does not override the cancellation terms.
Medication and evidence
Compounded medication is not FDA-approved, and the monitoring system’s device clearance does not extend to the drugs or prove the effectiveness of the complete Signos+ program. FDA advises that compounded drugs should be used only when an individual’s needs cannot be met by an approved medicine. Discuss that need with the prescriber and request the actual dispensing pharmacy, formulation, concentration and instructions before the first shipment. Those details are especially important when transferring from a pen or another compounded product. A glucose display also does not demonstrate that an injection contains the intended dose or establish why weight changed. Signos labels some charts as illustrative and some outcomes as internal member data; they should be read in that context. The strongest consumer case is the convenience of coordinated tools and support. Whether the sensors justify the term cost depends on their practical use, the clinician’s assessment and the patient’s willingness to complete ongoing check-ins.
Sources checked October 25, 2026
- Official Signos+ treatment, eligibility and device disclosures
- Official plan inclusions and check-in refund limits
- Official sensor quantities, additional cost and clinical contact
- Official subscription and pharmaceutical cancellation terms
- Official renewal cancellation and remaining-payment explanation
- Official insurance and HSA/FSA payment limitations
- FDA concerns and patient-specific limits on compounded GLP-1 drugs
Pros and watch-outs
What we like
- Medication, app and periodic sensors in one program
- Explicit sensor quantities and extra-sensor pricing
- Separate contacts for clinical and technical support
- Nutrition support and monthly clinical check-ins
Watch-outs
- Compounded drugs are not FDA-approved
- Included sensors provide intermittent coverage
- Term payments can continue after renewal cancellation
- Louisiana excluded; age and clinical restrictions apply
Best for
Eligible adults interested in periodic glucose feedback and ongoing logging who can commit to the treatment term and discuss compounded medication with the prescriber.
Who should look elsewhere
Patients seeking FDA-approved branded treatment, continuous sensor coverage included for the entire term, or unrestricted monthly cancellation.
Research relevant to Signos
Explore the evidence and its limits. Findings apply to the formulation, route and population studied; they do not establish the quality or effectiveness of a provider’s products.
- What the semaglutide weight-loss trials actually showed
STEP 1, STEP 4 and SELECT, plus oral and higher-dose semaglutide trials: weight loss, withdrawal, cardiovascular benefit and the limits of comparison.
- SURMOUNT-1 explained: the trial that made tirzepatide the benchmark
The landmark phase 3 trial of tirzepatide for obesity — the design, the up-to-20.9% weight loss, the safety profile, and the limits of what it proved.
How Signos compares
A few alternatives worth a look, depending on what you’re optimizing for.
- HumeCare+
Tracking lean mass rather than scale weight, if you read the guarantee terms first
See HumeCare+ →
SkinnyRxStraightforward compounded GLP-1 access with cancel-anytime flexibility
See SkinnyRx →
RoBranded treatment with medication insurance navigation
See Ro →
More GLP-1 telehealth reviews: Synergy RxCareBareRXHe & She MDSuperior RemediesTry AgelessNovi
Editorial research
How we assessed this. This review reflects Aminoscope’s own read of Signos’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- Are sensors included for continuous wear throughout the plan?
- No. The help center lists two 15-day sensors for three months and four for six months. Additional sensors cost extra.
- Does FDA clearance cover the GLP-1 medicine?
- No. Device clearance concerns the monitoring system. Signos+ says all its GLP-1 medicines are compounded and are not FDA-approved.
- Does canceling renewal erase the remaining term payments?
- No. The cancellation help page says remaining payments for the active term continue. The pharmaceutical terms also require 72 hours’ notice before a billing date.
- Is Signos legit?
- Signos is a GLP-1 telehealth service. The medications it names are Compounded semaglutide and Compounded tirzepatide. Its stated availability: 49 states and DC; Louisiana excluded; generally ages 18–74, Nebraska 19+. What it publishes up front: From $199/mo headline for 3- or 6-month terms; limited sensors; verify full term and renewal; Louisiana excluded. It is cash-pay and states it does not bill insurance. Before you pay, ask in writing about a single monthly price you can check before an intake and how its intake works.