CJC-1295 vs Sermorelin
Both are GHRH analogs acting on the same receptor. The real difference is regulatory: sermorelin has a pediatric clinical record and a compounding route; CJC-1295 is research-only.
CJC-1295
Sustained GH/IGF-1 rise shown in humans — a surrogate marker, not the body-composition outcome it is sold for.
Full CJC-1295 evidence reviewSermorelin
Geref
A former FDA-approved GHRH analog (now compounded); real GH-axis data, no anti-aging outcome evidence.
Full Sermorelin evidence reviewSide by side
| CJC-1295 | Sermorelin | |
|---|---|---|
| Marketed for | Muscle, recovery, 'anti-aging' | GH deficiency, 'anti-aging' |
| Evidence grade | Clinical data | Clinical data |
| Family | GH axis | GH axis |
| Regulatory status | Not FDA-approved | Not FDA-approved |
| How it's obtained | Research-only | Compounded |
| Key human source | Teichman, JCEM 2006 | BioDrugs review, 1999 |
marks a row where the two differ. Evidence grades come from our evidence matrix, which grades each molecule on the human data for the use it is marketed for.
Our verdict
Sermorelin is the better documented of the two, though its evidence-backed role is narrow: the diagnosis and treatment of idiopathic growth-hormone deficiency in children. Its anti-aging use rests on biomarker effects rather than healthspan outcomes. CJC-1295 has one strong human pharmacology result, sustained multi-day elevations in GH and IGF-1 after single injections, but that is a surrogate marker, and CJC-1295 is not approved for anything; it is sold research-only, with unverified dose and purity. The two have not been compared directly, and neither has human body-composition outcome data.
CJC-1295 fits if
CJC-1295 is the molecule to read about if your question is how long a GHRH signal can be stretched pharmacologically; it is not a prescribable product.
Sermorelin fits if
Sermorelin is the more relevant one for a reader working with a clinician, since it has a genuine clinical history and is still supplied through compounding pharmacies.
Where to get it
Where to get peptide therapy
Clinician-led telehealth services that prescribe compounded peptides. The specific peptides offered vary by provider — confirm CJC-1295 & Ipamorelin availability before ordering.
