Medsol RX review
Clear monthly prices, coach included
A telehealth platform using OpenLoop clinicians to prescribe compounded semaglutide and tirzepatide month to month or on prepaid plans, with a care coach in every plan and NAD⁺ and sermorelin on the side.
Our verdict
Medsol RX prints a month-to-month price for each compounded GLP-1 on its packages page. Semaglutide tablets are $179 every month, semaglutide injections $169 for the first month and $199 after, and tirzepatide injections $239 and then $259, with lower monthly rates if you prepay three, six or twelve months. Every weight-loss plan comes with a one-on-one care coach, and the prescribing is done by clinicians from OpenLoop, a large national telehealth network, with pharmacies named in its terms. The weak spots are in the copy around those prices. Its product pages quote much wider "typical" ranges ($250 to $1,400 for tirzepatide, $250 to $800 for NAD⁺) that don't match the packages page, and its FAQ says compounded GLP-1s contain the same active ingredients as Ozempic and Wegovy and are made to the same standards, which overstates things for drugs the FDA hasn't approved. Monthly billing isn't refunded once a month starts, and you need to cancel 72 hours before the next charge. For a buyer who wants to pay month to month with coaching included, the terms are easy to read up front.
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At a glance
- Category
- GLP-1 telehealth
- Access
- Month-to-month: compounded semaglutide tablets $179/mo, injections $199/mo after a $169 first month, tirzepatide $259/mo after $239; prepaid plans lower; Ozempic $1,229/mo, Zepbound $1,399/mo
- Medications
- Compounded semaglutide · Compounded tirzepatide · Ozempic or Zepbound
- Insurance
- Cash-pay, no insurance
- Visit
- Quiz intake / Async intake / Video visit
Partner alternative
Enhance MD
Lab-guided treatment under ongoing physician oversight
Check Enhance MD availability →What it is
Medsol RX is a telehealth weight-loss and wellness platform that says it's headquartered in Florida, with a North Carolina phone number for support. Its terms and disclaimers say final prescribing decisions are made by OpenLoop's licensed U.S. clinicians after a telehealth review, and they name four partner pharmacies: Red Rock Compounding Pharmacy in Utah, HealthWarehouse in Kentucky, Precision Medicine in New York and Triad Rx in Alabama. Besides compounded and brand-name GLP-1s, it sells a wellness menu of NAD⁺, sermorelin, B12-MIC, glutathione, L-carnitine, lipo-C and methylene blue. It's cash-pay, accepts HSA and FSA cards, offers Klarna financing, and says it serves patients nationwide.
How it works
You take a free online assessment, which the site says takes under five minutes, then a licensed OpenLoop clinician reviews it, by telehealth consultation where required, and builds a treatment plan. Medication is filled by a partner pharmacy and shipped to your door within a few business days. Every weight-loss plan pairs you with a dedicated care coach for goal setting, nutrition guidance and regular check-ins, and the medical team stays involved for dose changes. A separate microdosing track starts patients on lower doses, and the FAQ lists the usual exclusions, including a personal or family history of medullary thyroid cancer or MEN 2, pancreatitis, and pregnancy or breastfeeding. Wellness subscriptions such as NAD⁺ and sermorelin come without coaching.
Pricing transparency
The packages page sets out each compounded GLP-1 two ways. Paying month to month, semaglutide tablets cost $179 a month, semaglutide injections $169 for month one and $199 from month two, and tirzepatide injections $239 for month one and $259 from month two. Prepaid plans cost less per month: semaglutide injections $169, $149 or $129 a month on 3-, 6- or 12-month plans (billed $507, $894 or $1,548), tirzepatide $229, $209 or $199 (billed $687, $1,254 or $2,388), and semaglutide tablets $159, $139 or $119. Low-dose microdosing options are $149 a month with coaching, and brand-name Ozempic and Zepbound pens cost $1,229 and $1,399 a month. Its individual product pages quote broader ranges that don't match, so rely on the packages page and confirm at checkout. Your subscription starts once you complete the intake and pay for the first month; if a provider disqualifies you, you're refunded. You can cancel any time, but the request must arrive at least 72 hours before your next billing date, monthly charges aren't refunded for the month you cancel in, and on a multi-month plan you're refunded only for months in which no medication shipped.
Branded vs compounded
Compounded semaglutide comes as a weekly injection or a tablet, and compounded tirzepatide as a weekly injection; the microdosing menu adds lower-dose tirzepatide dissolving tablets. Brand-name Ozempic and Zepbound are available as prefilled pens. The site's disclaimer states that compounded medications are not FDA-approved and haven't been evaluated by the FDA for safety, efficacy or quality, but its FAQ describes compounded GLP-1s as containing the same active ingredients as the brand-name drugs and made to the same clinical standards, and the packages page promises the tablets give the same clinical outcomes as injections; neither claim is established for compounded products. It shows a "LegitScript Approved" badge, and its footer links to LegitScript's search page rather than a numbered certification. A search of the FDA warning-letter database under the company's name and web address returned no letters. NAD⁺ (injection, nasal spray or dropper) and sermorelin (injection or dropper) are sold as separate subscriptions.
Pros and watch-outs
What we like
- Month-to-month price posted for every compounded GLP-1
- Care coach included in every weight-loss plan
- Clinicians from the OpenLoop network; pharmacies named
- Tablet, injection, microdose and brand-name options
- HSA, FSA and Klarna accepted
Watch-outs
- Product pages quote price ranges that don't match the packages page
- FAQ overstates how compounded drugs compare with brand-name ones
- No refund for the month you cancel in
- Cancellation needs 72 hours' notice before billing
- Brand-name pens cost $1,229 to $1,399 a month
Best for
Cash buyers who want a posted month-to-month price for compounded semaglutide or tirzepatide, with a coach included and the option of NAD⁺ or sermorelin on the same account.
Who should look elsewhere
Anyone who wants insurance billing, or a buyer who expects a refund for a month already started.
The evidence behind what Medsol RX prescribes
We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.
- What the semaglutide weight-loss trials actually showed
STEP 1, STEP 4, and SELECT — the efficacy, the rebound, and the cardiovascular signal, read straight from the primary literature.
- Tirzepatide vs semaglutide for weight loss: what the trials actually support
Most comparisons are cross-trial. Only SURPASS-2 and SURMOUNT-5 randomized one drug against the other — here's the precise distinction.
- Compounded vs branded GLP-1: regulatory status, sourcing and the evidence
Compounded GLP-1 isn't FDA-approved, the shortage exception behind it ended in 2025, the FDA moved against mass-marketed copies in 2026, and the trial data belong to the branded product. Here's the precise picture.
- NAD+ precursors (NR and NMN): what the human trials actually show
They raise NAD+ and look safe short-term, but human evidence is surrogate-marker level, and no trial shows they extend healthspan.
- Sermorelin benefits: does it work? What the trials show
A real GHRH drug, read against the anti-aging pitch: an approved growth-hormone-releasing analog with a pediatric track record, and a longevity case built more on biomarkers than outcomes.
How Medsol RX compares
A few alternatives worth a look, depending on what you’re optimizing for.
WellMedRxCompounded GLP-1s by injection or tablet, with a named clinician network and pharmacy
See WellMedRx →- Enhance MD
Lab-guided treatment under ongoing physician oversight
See Enhance MD → 
KovaPeople who want a compounded GLP-1 with an app that keeps them on top of doses, protein and side effects
See Kova →
More GLP-1 telehealth reviews: Fifty 410Fitness RXFitstryFlorida Weight Loss MDFormBlendsFound Youth
Access & cost
How we assessed this. This review reflects Aminoscope’s own read of Medsol RX’s publicly-stated model — pricing transparency, clinical oversight, medication clarity, and access — against our editorial methodology. We publish no fabricated ratings or first-hand outcomes. A partnership never changes the assessment — see how we make money.
Frequently asked
- How much does Medsol RX cost?
- Month to month, compounded semaglutide tablets are $179, semaglutide injections $199 after a $169 first month, and tirzepatide injections $259 after a $239 first month. Prepaid 3-, 6- and 12-month plans cost less per month.
- Is a coach included?
- Yes. Every weight-loss plan includes a dedicated one-on-one care coach for goal setting, nutrition guidance and check-ins.
- How do I cancel Medsol RX?
- Contact support by email, phone or the patient portal at least 72 hours before your next billing date. The month you cancel in isn't refunded.
- Does Medsol RX sell NAD⁺ and sermorelin?
- Yes. NAD⁺ comes as an injection, nasal spray or dropper and sermorelin as an injection or dropper, priced from $209 and $149 a month on 4-week plans on its packages page.
- Who prescribes at Medsol RX?
- Licensed clinicians from OpenLoop make the final prescribing decisions after a telehealth review.
- Is Medsol RX legit?
- Medsol RX is a GLP-1 telehealth service you reach through an online questionnaire, an online intake a clinician reviews and a video visit with a clinician. The medications it names are Compounded semaglutide, Compounded tirzepatide and Ozempic or Zepbound. What it publishes up front: Month-to-month: compounded semaglutide tablets $179/mo, injections $199/mo after a $169 first month, tirzepatide $259/mo after $239; prepaid plans lower; Ozempic $1,229/mo, Zepbound $1,399/mo. It is cash-pay and states it does not bill insurance. Before you pay, ask in writing about which states it serves.
- Is Medsol RX expensive compared with other GLP-1 telehealth providers?
- Medsol RX publishes a starting figure of $179/mo. Across the 112 GLP-1 telehealth providers we review that publish a single monthly figure, those run $49 to $399 with a median of $179, which puts Medsol RX right at the median. The other 173 GLP-1 telehealth providers we review quote only after an intake or price by dose, so they are not in that comparison. A starting figure is not a bill — labs, consultations and shipping are often charged separately, so confirm what your own quote includes.