Does losing weight on a GLP-1 raise testosterone?

In men with obesity, losing weight tends to raise testosterone, and studies of weight loss in overweight and obese men found the rise grew with the amount lost. Whether a GLP-1 gets a particular man's level back into the normal range depends on how low it started and why, so a repeat morning test after meaningful weight loss is the way to find out.

Can I take testosterone and a GLP-1 at the same time?

Many men do, and every service on this page can prescribe both. Each has its own monitoring: testosterone needs periodic blood counts and testosterone levels, and a GLP-1 needs dose steps and a watch on side effects. Tell each prescriber about the other medication, and having one clinician see both lab sets is the main reason to keep them in one account.

Should men use a different GLP-1 dose than women?

No. Semaglutide and tirzepatide follow the same label dose steps for everyone, and the prescriber adjusts to side effects and response. Men do tend to start at a higher body weight, so the absolute weight lost can be larger, but the percentage goals are the same.

GLP-1 for men

GLP-1 providers that also treat testosterone and ED

Semaglutide and tirzepatide work the same way in men and women. What differs for many men is the rest of the chart: low testosterone, erectile dysfunction and weight often show up together, and treating them through three separate services means three intakes, three sets of labs and three bills. Every service below runs a GLP-1 program and also treats low testosterone, ED, or both in the same account.

Short answer

21 GLP-1 services here also treat low testosterone or erectile dysfunction: 14 run testosterone care and 6 treat both. Pick one for the single account and shared labs, not for a different drug. If your testosterone is low and you carry extra weight, ask whether to recheck it after some weight loss before starting TRT.

By Julian RothResearch & data

21 providers comparedReviewed against our editorial methodologyUpdated August 2026

Disclosure: Aminoscope is reader-supported. Some links below are affiliate links — if you start care through them we may earn a commission, at no extra cost to you. Partners are listed first; a commission never changes what we write about a provider. How we make money.

The shortlist

21 providers, side by side

Included: GLP-1 services that also treat low testosterone or erectile dysfunction, shown by a row on our TRT or ED board or by the company's own menu as described in its review. The Access cell lists that men's-health care first, then the GLP-1 price. Partners are listed first; the order is commercial, not a ranking.

Sort

Provider	Access	Medications	Insurance	Visit	Go
HealthRXPartner Low-cost, overnight Read review →	ED: ED meds and PT-141 via online physician review; overnight shipping. GLP-1: compounded semaglutide $165 a month	SemaglutideTirzepatide	Cash-pay	Async	Check availability
Bodybuilding Health+Partner Fitness-oriented Read review →	ED: tadalafil and sildenafil in its sexual-performance program. GLP-1: compounded semaglutide $179 a month	SemaglutideTirzepatide	Cash-pay	Async	Check availability
Peter MDPartner Men's-health one-stop Read review →	Testosterone: injectable and oral testosterone, HCG and enclomiphene	SemaglutideTirzepatide	Cash-pay	Video	Check availability
WellMedRxPartner Named pharmacy, no price Read review →	Testosterone: Enclomiphene with anastrozole or tadalafil rather than testosterone; Mycelium Pharmacy named; no price published; shortest plan renews every 21 days	SemaglutideTirzepatide	—	Async	Check availability
He & She MD Flat dosing, prepay headline Read review →	Testosterone: Testosterone injection $179/mo month-to-month, $119 on 12 months; enclomiphene $189–$139; states not published. ED: On-demand from $10/dose, same price at every dose; daily and combination options; states not published. GLP-1: compounded semaglutide $199 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Ro Polished, insurance help Read review →	ED: ED treatment in the same account. GLP-1: Medication billed separately from a $149/mo membership	Branded	Insurance	VideoAsync	Check availability
Hims Mainstream, app-first Read review →	Testosterone: Testosterone support (enclomiphene), labs included. ED: Generic PDE5 inhibitors, subscription. GLP-1: Medication from $149/mo plus a $149/mo membership, about $298 all-in	Branded	Cash-pay	VideoAsync	Check availability
Henry Meds Flat-fee, simple Read review →	Testosterone: From $129/mo (oral $179/mo). GLP-1: compounded semaglutide $297 a month	SemaglutideTirzepatide+1	Cash-pay	VideoAsync	Check availability
CeliaRx Read review →	ED: One-time SKU checkout — PT-141 nasal spray $349, PT-141 lozenge $349, tadalafil/sildenafil/oxytocin triturate $399. $55 video consult required before fulfillment	Compounded semaglutideCompounded tirzepatide	Cash-pay	Video	Check availability
EdgeRx Compounded, flat monthly pricing Read review →	ED: PT-141/oxytocin/Olympus protocols run $129–$249/mo depending on formulation; enclomiphene and gonadorelin (natural-production support, not TRT) run $89–$129/mo. Async questionnaire, 24h physician review. Not available in Arkansas, Indiana, Minnesota, or South Carolina. GLP-1: compounded semaglutide $229 a month	Compounded semaglutide + glycine/B12Compounded tirzepatide + glycine/B12	Cash-pay	QuizAsync	Check availability
Pepti Every route, priced openly Read review →	Testosterone: Testosterone cypionate $109/mo, cream $159, TRT + anastrozole $129; hormone panel $199; 36 states. ED: Tadalafil troche $79/mo, sildenafil $179, Trimix $159; PT-141 $189–$219 by route; 36 states. GLP-1: compounded semaglutide $99 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Rehydra+ Wellness Entry price rises with dose Read review →	Testosterone: Testosterone therapy $399 — ester, route, dose and supply length unspecified; 20 states, not listed. GLP-1: compounded semaglutide $119 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Lighter You Coaching included, headline off Read review →	ED: Tadalafil $112 per 4 weeks; the higher “Powered” tiers stack 2–3 PDE5 inhibitors, $96–$119. Molecules named only at checkout. GLP-1: compounded semaglutide $249 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
AHBARx Honest prepay arithmetic Read review →	ED: Tadalafil, sildenafil and PT-141 sold as oxytocin combinations; all 50 states; pharmacy unnamed. GLP-1: compounded semaglutide $249 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Bayan Health Low entry, broad menu Read review →	Testosterone: TRT $299; men's hormone panel $189; enclomiphene $69/mo as the alternative. Nationwide. ED: Sildenafil and tadalafil $49/mo each on a 3-month plan; combination $59; PT-141 $199. Nationwide. GLP-1: compounded semaglutide $129 a month	Compounded semaglutideCompounded tirzepatide+1	Cash-pay	QuizAsync	Check availability
NEUVÉ Health Every route priced Read review →	Testosterone: Testosterone cypionate from $127/mo; initial panel $133 and maintenance $103, itemized. ED: PT-141, tadalafil and oxytocin in injection, oral and troche form; lab panels itemized $45–$301. GLP-1: compounded semaglutide $138 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizVideo	Check availability
Nex Gen Health Rx Banner and catalog disagree Read review →	Testosterone: Injectable TRT with oral TRT listed as coming soon; Manifest Pharmacy (503A) named throughout. ED: ED from $60/mo, premature ejaculation from $60, PT-141 from $189; Manifest Pharmacy (503A) named. GLP-1: compounded semaglutide $190 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizVideo	Check availability
Nova All-in price quoted Read review →	Testosterone: Testosterone cypionate, oral and sublingual from $96/mo plus a $99/mo membership; 49 states. GLP-1: compounded semaglutide $198 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
RENN Health One bill, operator unnamed Read review →	Testosterone: TRT page published, no testosterone-specific price; subscription from $149/mo. All 50 states. GLP-1: compounded semaglutide $149 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Prime Doctor RX Both prices on the card Read review →	Testosterone: TRT from $119/mo on the longest prepay, month-to-month available; initial hormone labs $50; pharmacy unnamed. GLP-1: compounded semaglutide $249 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability
Science & Co Cheap on a 12-month tie Read review →	Testosterone: Testosterone injection, cream and enclomiphene; lab-confirmed before prescribing. No price published for TRT. GLP-1: compounded semaglutide $149 a month	Compounded semaglutideCompounded tirzepatide	Cash-pay	QuizAsync	Check availability

HealthRXPartnerLow-cost, overnight
Low-cost compounded GLP-1 with overnight shipping and physician review
Access
ED: ED meds and PT-141 via online physician review; overnight shipping. GLP-1: compounded semaglutide $165 a month
Insurance
Cash-pay
Medications
SemaglutideTirzepatide
Visit
Async
Check availability
Bodybuilding Health+PartnerFitness-oriented
GLP-1 alongside NAD⁺ and sermorelin from a fitness brand
Access
ED: tadalafil and sildenafil in its sexual-performance program. GLP-1: compounded semaglutide $179 a month
Insurance
Cash-pay
Medications
SemaglutideTirzepatide
Visit
Async
Check availability
Peter MDPartnerMen's-health one-stop
GLP-1 from a men's-health provider that also covers TRT and longevity
Access
Testosterone: injectable and oral testosterone, HCG and enclomiphene
Insurance
Cash-pay
Medications
SemaglutideTirzepatide
Visit
Video
Check availability
WellMedRxPartnerNamed pharmacy, no price
Compounded GLP-1s by injection or tablet, with a named clinician network and pharmacy
Access
Testosterone: Enclomiphene with anastrozole or tadalafil rather than testosterone; Mycelium Pharmacy named; no price published; shortest plan renews every 21 days
Insurance
—
Medications
SemaglutideTirzepatide
Visit
Async
Check availability
He & She MDFlat dosing, prepay headline
Flat per-dose GLP-1 pricing across injectable and oral, if you read the ladder before the banner
Access
Testosterone: Testosterone injection $179/mo month-to-month, $119 on 12 months; enclomiphene $189–$139; states not published. ED: On-demand from $10/dose, same price at every dose; daily and combination options; states not published. GLP-1: compounded semaglutide $199 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
RoPolished, insurance help
A polished, well-resourced end-to-end program
Access
ED: ED treatment in the same account. GLP-1: Medication billed separately from a $149/mo membership
Insurance
Insurance
Medications
Branded
Visit
VideoAsync
Check availability
HimsMainstream, app-first
An app-first experience from a mainstream brand
Access
Testosterone: Testosterone support (enclomiphene), labs included. ED: Generic PDE5 inhibitors, subscription. GLP-1: Medication from $149/mo plus a $149/mo membership, about $298 all-in
Insurance
Cash-pay
Medications
Branded
Visit
VideoAsync
Check availability
Henry MedsFlat-fee, simple
Simple flat-fee compounded access without insurance
Access
Testosterone: From $129/mo (oral $179/mo). GLP-1: compounded semaglutide $297 a month
Insurance
Cash-pay
Medications
SemaglutideTirzepatideOral
Visit
VideoAsync
Check availability
CeliaRx—
Buyers who want a-la-carte GLP-1 dosing without committing to a subscription plan
Access
ED: One-time SKU checkout — PT-141 nasal spray $349, PT-141 lozenge $349, tadalafil/sildenafil/oxytocin triturate $399. $55 video consult required before fulfillment
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
Video
Check availability
EdgeRxCompounded, flat monthly pricing
Men already using EdgeRx's other peptide protocols who want GLP-1 folded into the same subscription
Access
ED: PT-141/oxytocin/Olympus protocols run $129–$249/mo depending on formulation; enclomiphene and gonadorelin (natural-production support, not TRT) run $89–$129/mo. Async questionnaire, 24h physician review. Not available in Arkansas, Indiana, Minnesota, or South Carolina. GLP-1: compounded semaglutide $229 a month
Insurance
Cash-pay
Medications
Compounded semaglutide + glycine/B12Compounded tirzepatide + glycine/B12
Visit
QuizAsync
Check availability
PeptiEvery route, priced openly
Buyers who want a wide set of GLP-1 routes with a price published against each
Access
Testosterone: Testosterone cypionate $109/mo, cream $159, TRT + anastrozole $129; hormone panel $199; 36 states. ED: Tadalafil troche $79/mo, sildenafil $179, Trimix $159; PT-141 $189–$219 by route; 36 states. GLP-1: compounded semaglutide $99 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
Rehydra+ WellnessEntry price rises with dose
Buyers who want a low entry dose and accept the price rising as they titrate
Access
Testosterone: Testosterone therapy $399 — ester, route, dose and supply length unspecified; 20 states, not listed. GLP-1: compounded semaglutide $119 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
Lighter YouCoaching included, headline off
Buyers who want dietitian visits and coaching bundled into a GLP-1 plan
Access
ED: Tadalafil $112 per 4 weeks; the higher “Powered” tiers stack 2–3 PDE5 inhibitors, $96–$119. Molecules named only at checkout. GLP-1: compounded semaglutide $249 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
AHBARxHonest prepay arithmetic
A straightforward monthly GLP-1 price with the prepay math shown honestly beside it
Access
ED: Tadalafil, sildenafil and PT-141 sold as oxytocin combinations; all 50 states; pharmacy unnamed. GLP-1: compounded semaglutide $249 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
Bayan HealthLow entry, broad menu
Readers who want a microdose entry point and their lab work priced in the same catalog
Access
Testosterone: TRT $299; men's hormone panel $189; enclomiphene $69/mo as the alternative. Nationwide. ED: Sildenafil and tadalafil $49/mo each on a 3-month plan; combination $59; PT-141 $199. Nationwide. GLP-1: compounded semaglutide $129 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatideRetatrutide / orforglipron / cagrilintide
Visit
QuizAsync
Check availability
NEUVÉ HealthEvery route priced
Readers comparing injection against sublingual, and microdose against standard, on price
Access
Testosterone: Testosterone cypionate from $127/mo; initial panel $133 and maintenance $103, itemized. ED: PT-141, tadalafil and oxytocin in injection, oral and troche form; lab panels itemized $45–$301. GLP-1: compounded semaglutide $138 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizVideo
Check availability
Nex Gen Health RxBanner and catalog disagree
Buyers who want the 503A pharmacy named and the prepay total shown, not a monthly average
Access
Testosterone: Injectable TRT with oral TRT listed as coming soon; Manifest Pharmacy (503A) named throughout. ED: ED from $60/mo, premature ejaculation from $60, PT-141 from $189; Manifest Pharmacy (503A) named. GLP-1: compounded semaglutide $190 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizVideo
Check availability
NovaAll-in price quoted
Readers who want the membership included in the quoted price rather than added at checkout
Access
Testosterone: Testosterone cypionate, oral and sublingual from $96/mo plus a $99/mo membership; 49 states. GLP-1: compounded semaglutide $198 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
RENN HealthOne bill, operator unnamed
One subscription and one care team across GLP-1, NAD+ and testosterone
Access
Testosterone: TRT page published, no testosterone-specific price; subscription from $149/mo. All 50 states. GLP-1: compounded semaglutide $149 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
Prime Doctor RXBoth prices on the card
Readers who want the month-to-month price printed beside the prepay price
Access
Testosterone: TRT from $119/mo on the longest prepay, month-to-month available; initial hormone labs $50; pharmacy unnamed. GLP-1: compounded semaglutide $249 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability
Science & CoCheap on a 12-month tie
A low GLP-1 rate if a twelve-month commitment is realistic for you
Access
Testosterone: Testosterone injection, cream and enclomiphene; lab-confirmed before prescribing. No price published for TRT. GLP-1: compounded semaglutide $149 a month
Insurance
Cash-pay
Medications
Compounded semaglutideCompounded tirzepatide
Visit
QuizAsync
Check availability

We never show a fabricated price or rating. Facts are shown only where a provider publishes them.

Why weight and testosterone are often treated together

Obesity is the most common reversible cause of low testosterone in men. Fat tissue converts testosterone to estradiol, and excess weight blunts the brain’s signal to the testes, so total testosterone tends to fall as waist size rises. The reverse also holds: in studies of overweight and obese men, losing weight raised testosterone, and the rise grew with the amount of weight lost. That is why a careful clinician confirms a low reading with a repeat morning blood test and looks at weight, sleep and medications before prescribing testosterone. Our guide to treating low testosterone walks through that order, and TRT vs raising testosterone naturally ranks the levers.

None of that means a GLP-1 replaces testosterone therapy. A man with confirmed hypogonadism and symptoms may need treatment either way. The practical advantage of the services on this page is that one clinician can see the testosterone level, the weight trend and the medication list at once, and can order a single lab panel instead of two.

Testosterone therapy, enclomiphene and fertility

The rows above use two different words for hormone care, and the difference matters if you may want children. Testosterone replacement (injections, cream or oral testosterone) adds testosterone from outside the body, and it switches off the signal that drives sperm production. Enclomiphene and HCG work the other way: they push the body to make more of its own testosterone and preserve fertility. Several services here sell enclomiphene and describe it as support for natural production rather than TRT, which is accurate. If fertility matters to you, say so at intake and ask which of the two the clinician plans to prescribe.

Protecting muscle while the scale drops

Any large weight loss takes some lean mass with the fat. In trials of GLP-1 drugs, lean tissue has accounted for roughly a quarter to a third of the weight lost, a share broadly similar to other ways of losing weight, and body-composition studies show people ending up proportionally leaner. For a man who lifts, the useful moves are resistance training at least two or three times a week and enough protein to support it. Testosterone therapy is sometimes pitched as muscle insurance; it is a treatment for confirmed low testosterone, not a routine add-on. The lean-mass evidence has the numbers.

What to ask before you put it all in one account

Ask how each line is billed. Some services charge one membership that covers every treatment; others price the GLP-1, testosterone and ED medication separately, and a few add a membership on top of each. Ask which labs are required for testosterone (a morning total testosterone, and usually a blood count because TRT can raise hematocrit) and whether the GLP-1 program needs its own. If you take an ED medication, ask whether your blood pressure has been checked recently, since PDE5 inhibitors lower it and large weight loss often does too. And confirm the same clinician, or at least the same chart, covers every prescription.

How we judge providers

Pricing transparency — is the all-in monthly cost clear, or does a low headline hide consults, labs, and medication fees?
Clinical oversight — real clinician review and dose titration, not a rubber-stamp questionnaire.
Branded vs compounded clarity — does the provider tell you plainly which you’re getting? (It matters — see our compounded-vs-branded explainer.)
Honest insurance handling — straight answers about what is and isn’t covered.

We never show a fabricated price or rating, and access notes appear only where a provider publishes them. Pricing and availability change often — confirm current details on the provider’s own site.

Keep comparing

Weighing testosterone care on its own? See the TRT providers and ED treatment options. For the drug itself, compare the compounded semaglutide and tirzepatide price lists, or see every service in the GLP-1 provider roundup.

Choosing between two services? Every provider head-to-head is on one page, including Ro vs SkinnyRx, Hims vs FORM Health and Direct Meds vs PlushCare.

Common questions

Does losing weight on a GLP-1 raise testosterone?: In men with obesity, losing weight tends to raise testosterone, and studies of weight loss in overweight and obese men found the rise grew with the amount lost. Whether a GLP-1 gets a particular man's level back into the normal range depends on how low it started and why, so a repeat morning test after meaningful weight loss is the way to find out.
Can I take testosterone and a GLP-1 at the same time?: Many men do, and every service on this page can prescribe both. Each has its own monitoring: testosterone needs periodic blood counts and testosterone levels, and a GLP-1 needs dose steps and a watch on side effects. Tell each prescriber about the other medication, and having one clinician see both lab sets is the main reason to keep them in one account.
Is enclomiphene the same as testosterone replacement?: No. Testosterone replacement supplies the hormone directly and suppresses sperm production. Enclomiphene signals the body to make more of its own testosterone and preserves fertility. Several services here sell enclomiphene and say plainly that it is natural-production support, not TRT.
Should men use a different GLP-1 dose than women?: No. Semaglutide and tirzepatide follow the same label dose steps for everyone, and the prescriber adjusts to side effects and response. Men do tend to start at a higher body weight, so the absolute weight lost can be larger, but the percentage goals are the same.