Apex MD review

What it is

Apex MD is a US virtual telemedicine platform, licensed in all 50 states and DC, that prescribes compounded GLP-1 medication for weight loss. Its compounds are formulated with NAD, B-12 and L-carnitine added — which is why it appears on this board — and it offers both weekly injections and daily oral formulations, plus a GLP-1 microdosing option. Plans include unlimited provider visits and Labcorp labs at no extra fee, with delivery typically inside four business days.

How it works

Virtual telemedicine with an unusually generous inclusion list: unlimited provider visits and Labcorp lab work are part of the plan rather than billed on top, which is the reverse of the membership-plus-labs-plus-medication structure common elsewhere. For a weight-loss program that is a real benefit — titration is a conversation, and being able to have it without a per-visit charge changes behaviour. What that model does not give you is any control over the NAD component. It is fixed in the compound at whatever the formulation specifies, so it is not something you or your clinician can adjust, monitor or stop independently of the GLP-1. If your interest is NAD⁺ specifically, that is a design constraint, not a feature.

Pricing transparency

Apex MD publishes its full price list, which is more than most of this batch manages: compounded semaglutide injection at $299/mo and tirzepatide at $399/mo, with the daily oral versions at $349/mo and $419/mo, each including unlimited visits and Labcorp labs. Those are weight-loss prices, and there is no separate NAD⁺ price to quote because there is no separate NAD⁺ product — the additive is bundled into the compound. Compare it against other GLP-1 services on the all-in figure, since a cheaper headline elsewhere that excludes visits and labs is not the same purchase. It does not publicly name its compounding pharmacy.

Branded vs compounded

Compounded; not FDA-approved. Prescription required only if a licensed provider finds it appropriate. The GLP-1 products are compounding-pharmacy preparations, not therapeutically equivalent to branded semaglutide or tirzepatide, and the pharmacy behind them is not named. The NAD question deserves to be answered directly rather than softened. Adding NAD to a compounded GLP-1 vial has no controlled human evidence supporting it — there is no trial showing the combination outperforms the GLP-1 alone on weight, energy, or anything else — and it is not equivalent to a dedicated NAD⁺ protocol. More broadly, injected NAD⁺ in any form lacks controlled outcome trials; the one human intravenous study was a pharmacokinetic pilot that found infused NAD⁺ clears from plasma quickly. The NAD⁺ evidence that does exist sits with the oral precursors NR and NMN, which reliably raise blood NAD⁺ in controlled studies — a raised biomarker, not a demonstrated clinical outcome. There is also a practical point: multi-ingredient compounds make it harder to attribute either a benefit or a side effect to any single component. Individual results vary.

Pros and watch-outs

The evidence behind what Apex MD prescribes

We grade the molecules, not the marketing. Here is what the human data actually shows for each thing on their menu.

• NAD+ precursors (NR and NMN): what the human trials actually show

  They raise NAD+ and look safe short-term — but human evidence is surrogate-marker level, and no trial shows they extend healthspan.

How Apex MD compares

A few alternatives worth a look, depending on what you’re optimizing for.

• TNTru Niagen

  The most clinically-studied oral NAD⁺ precursor (NR)

  See Tru Niagen →
• RBRenue By Science

  Liposomal/sublingual NMN with posted lab testing

  See Renue By Science →
• Invigor Medical

  Prescription at-home NAD⁺ injections via telehealth

  See Invigor Medical →